TIM3 expression in AML

Focused scRNA-seq reanalysis of AML datasets with regard to HAVCR2 (encoding TIM3) expression and its ligands.
The data needs to be downloaded from NCBI Geo / figshare.
The analyses use a bone marrow reference data, which will have to be generated as well using the vignette provided by Seurat.

Utilized datasets:

normal bone marrow

Huo et al., Science Immunology 2023 link

newly diagnosed AML

van Galen et al., Cell 2019 link

Beneyto-Calabuig et al., Cell Stem Cell 2023 link

transplant-naive relapse of AML

Abbas et al., Nature Communications 2021 link

Penter et al., Blood 2023 link

post-transplant relapse of AML

Penter et al., Blood 2023 link