This repository contains the codes used to compare the ORF-specific Ribo-seq profiles coming from different datasets and to assess the reproducibility of them.
Our analysis of the ORF-specific Ribo-seq profiles consist of two phases:
The upstream phase allows us to compute the Ribo-seq profiles starting from the raw Ribo-seq data
The downstream phase is the core of our method and is articulated as follows:
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Set up of the coverage matrix and elaboration of digitalised profiles
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Comparison of the digitalised profiles
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Assessment of the similarity scores
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Identification of the "significantly reproducible Ribo-seq profiles"