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valosekj committed Oct 11, 2023
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"The proposed normalization approach is performed per slice (not vertebral level) to avoid averaging within each vertebral level, as this could lead to a loss of information. This allows access to any specific range of slices in PAM50 space, which is beneficial, for example, in pathologies like spinal cord compression occurring at the intervertebral discs and spanning across several slices from adjacent levels.\n",
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"Compared to classical image-based registration, our normalization approach does not introduce geometrical image distortions, which may result in inaccuracies when computing morphometric measures. Traditional registration to the PAM50 template involves spinal cord straightening, vertebral alignment between the image and the template, and iterative slice-wise non-linear registration {cite:p}`DeLeener2017-fe`. Each of these steps might change the spinal cord shape and contour (see a relevant [issue on GitHub](https://github.com/sct-pipeline/dcm-metric-normalization/issues/3).\n",
"Compared to classical image-based registration, our normalization approach does not introduce geometrical image distortions, which may result in inaccuracies when computing morphometric measures. Traditional registration to the PAM50 template involves spinal cord straightening, vertebral alignment between the image and the template, and iterative slice-wise non-linear registration {cite:p}`DeLeener2017-fe`. Each of these steps might change the spinal cord shape and contour (see a relevant [issue on GitHub](https://github.com/sct-pipeline/dcm-metric-normalization/issues/3)).\n",
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"## 4.3 Interactive figures and Normative database\n",
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