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add strand flip check #67

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alkaZeltser
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@alkaZeltser alkaZeltser commented Oct 31, 2024

This PR adds allele match checking and strand flip correction functionality.

For some background on strand flipping, check out my new discussion post:
#68

@RoniHaas I would appreciate your review of the key strand flip function (assess.pgs.vcf.allele.match)

Closes #63

  • Add DNA flip function (flips alleles to reverse complement)
  • Add allele match check function (checks for various mismatch cases including strand flip, and corrects strand flips)
  • Incorporate strand flip checking into the main apply.polygenic.score function
  • Add tests for above
  • Update all documentation (README, manual, vignette)
  • Export all relevant new functions through NAMESPACE
  • Update NEWS with new feature

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Testing Results

All unit tests pass

@alkaZeltser alkaZeltser marked this pull request as draft October 31, 2024 01:01
@alkaZeltser alkaZeltser marked this pull request as ready for review November 25, 2024 22:02
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For those who are interested, check out the rendered manual:
ApplyPolygenicScore_2.0.0.pdf

And the rendered User Guide vignette:
UserGuide.pdf

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Add strand-flip handling
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