Title

Eccentric exercise improves joint flexibility in adults: A systematic review update and meta-analysis

Journal

Musculoskeletal Science and Practice

Authors

Joanna Diong [1], Peter C Carden [2], Kieran O’Sullivan [3], Catherine Sherrington [2,4], Darren S Reed [1]

1. School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, NSW, Australia
2. School of Public Health, Faculty of Medicine and Health, The University of Sydney, NSW, Australia
3. Ageing Research Centre and Sports and Human Performance Centre, University of Limerick, Ireland
4. Institute of Musculoskeletal Health, The University of Sydney and Sydney Local Health District, NSW, Australia

Corresponding author

Dr Joanna Diong
School of Medical Sciences
Faculty of Medicine and Health
The University of Sydney
Sydney, NSW 2006, Australia

Email: joanna.diong@sydney.edu.au

Data files

Data -> eccentric_R1.xlsx
Excel file of effect sizes extracted from full texts of trials included in the meta-analysis. Data from this file were used in the meta-analyses to generate Figures 2-5 of the manuscript.

Data -> EccentricexSR_DATA_2022-01-19_1344.xlsx
Excel file of descriptive data extracted into RedCap from full texts of trials included in the systematic review. Data from this file are not analysed with computer code; calculations were done in the spreadsheet.

Code files

Stata code files to perform meta-analysis and generate figures were written by Joanna Diong (Stata v16).

eccentric.do
Main script: Stata do file to analyse data. Calls Data->eccentric.xlsx, performs meta-analysis, plots figures.

eccentric-PI_R1.xlsx
Spreadsheet to calculate prediction interval of overall effect of eccentric exercise. Spreadsheet was obtained from www.meta-analysis-books.com.

scheme-lean3.scheme
Graph scheme. Place scheme-lean3.scheme in Stata directory Stata16->ado->base->s

Instructions to run analysis

Download all data and code files.
Open eccentric.do, change filepath to local folder (Line 44)

Ensure dependencies are installed. Run in Stata:

• ssc install metan, replace
• ssc install metafunnel, replace
• ssc install metabias, replace

Run eccentric.do.

Note: for ease and transparency, all raw and processed data are hosted in the OSF repository.

Calculation of 95% prediction interval

eccentric-PI.xlsx

Log files -> Log eccentric 25 May 2020 14h07m33s.log

The spreadsheet was obtaind from https://meta-analysis-books.com/

Enter data into spreadsheet from log file lines 66 to 145.

Outputs

Figures

• Graphs -> effectfunnel
• Graphs -> effectfunnel_by
• Graphs -> effectrand
• Graphs -> effectrandby_outcome
• Graphs -> effectrandby_compare2Rx
• Graphs -> effectrandby_limb
• Graphs -> effectrandSens

These are Stata .gph graph and .tif figures of

• funnel plots
• random-effects meta-analysis: pooled outcomes
• random-effects meta-analysis: separate range of motion and fascicle length outcomes
• random-effects meta-analysis by subgroup of comparisons against 2 interventions and no intervention
• random-effects meta-analysis by subgroup of upper and lower limbs

Log files

• Log files -> "Do eccentric 19 Jan 2022 12h24m48s.txt"
• Log files -> "Log eccentric 19 Jan 2022 12h24m48s.txt"

These are date and time-stamped files recording the Stata Do file code and Log of output.