aFC-n Software Package

Haplotype-aware modeling of cis-regulatory effects highlights the gaps remaining in eQTL data

@navaehsan @wickdChromosome @pejminister

The aFC-n tool calculates the effect size of conditionally independent Expression Quantitative Trait Loci (eQTLs) based on allelic Fold Change (aFC). This script calculates aFCs using least squares optimization (levenberg-marquardt) for a set of eQTLs given a set of gene expressions and phased VCF file. See the manuscript for method description. For future updates please see the GitHub page.