GitHub - ModelDBRepository/247704: Thalamocortical loop with delay for investigation of absence epilepsy (Liu et al 2019)

ModelDBRepository / 247704 Public

Notifications You must be signed in to change notification settings
Fork 1
Star 0

Thalamocortical loop with delay for investigation of absence epilepsy (Liu et al 2019)

modeldb.science/247704

Notifications

Name		Name	Last commit message	Last commit date
Latest commit History 2 Commits
TC_RT_CT_twodelaymodel.ode		TC_RT_CT_twodelaymodel.ode
readme.html		readme.html
screenshot.png		screenshot.png
screenshot1.png		screenshot1.png
screenshot2.png		screenshot2.png
screenshot3.png		screenshot3.png
screenshot4.png		screenshot4.png

Repository files navigation

<HTML>


The XPPAUT code for the paper:<br>

<b>
Y.Liu, J. Milton and S.A. Campbell (2019) </b> 
Outgrowing seizures in Childhood Absence Epilepsy: time delays and bistability
Journal of Computational Neuroscience, 
<a href="https://doi.org/10.1007/s10827-019-00711-x">doi:10.1007/s10827-019-00711-x</a>.

<p>
Details on installing XPPAUT can be found on 
<a href="http://www.math.pitt.edu/~bard/xpp/xpp.html">Bard Ermentrout's XPPAUT webpage</a>.
</p>

To reproduce figures in paper, all parameters can be left at default
values: (Initialconds -> Go)<p/>
   <img src="./screenshot.png" alt="screenshot 0" width="550"><p/>

except as follows.
<dl>
<dt><b>Figure 2</b>: (use Parameters menu, type variable name, value) (type escape key "esc" when done/ready to run the model) gd_AMPA=0,ge_AMPA=0. 
 <dd>Left: Itc_ext_c=5; 
   <p/>
   <img src="./screenshot1.png" alt="screenshot 1" width="550"><p/>
Right: Itc_ext_c=6<p/> Top gb_GABAA=0.6;
<dd>
   <img src="./screenshot2.png" alt="screenshot 2" width="550"><p/>
   Bottom: gb_GABAA=0.1
<dd>   <img src="./screenshot3.png" alt="screenshot 3" width="550"><p/>
   Middle gb_GABAA=0.3;
<dd>   <img src="./screenshot4.png" alt="screenshot 4" width="550"><p/>
<dt><b>Figure 3</b>: gd_AMPA=0,ge_AMPA=0. 
 <dd>Itc_ext_c=5, Itc_pert=1.5, ontime=2000, offtime=2500
 <dd>Left gb_GABAA=0.1; Middle gb_GABAA=0.4; Right: gb_GABAA=0.7

<dt><b>Figure 4</b>: Itc_ext=5, tau1=9, tau2=2.8 
 <dd>Top left gb_GABAA=0.6; Top right gb_GABAA=0.1; 
 <dd> Bottom left: gb_GABAA=0.29; Bottom right: gb_GABAA=0.2;  

<dt><b>Figure 5</b>: Itc_ext_c=5, tau2=2.8
 <dd>Left  gb_GABAA=0.6, tau1=4.2  
 <dd>Right gb_GABAA=0.5, tau1=8.4  

<dt><b>Figure 6</b>: Itc_ext_c=5, tau2=2.8, Itc_pert=1, ontime=2000, offtime=2300
 <dd>Left gb_GABAA=0.7; Right: gb_GABAA=0.4
 <dd>Top tau1=8.4; Bottom: tau1=2.8
</dl>

To modify the initial conditions for Figure 6 as described on page 7
of the paper, use the "delay ICs" window in XPPAUT.
</html>