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CITATION.cff
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# This CITATION.cff file was generated with cffinit.
# Visit https://bit.ly/cffinit to generate yours today!
cff-version: 1.2.0
title: GFE Search Generator
message: >-
If you use this software, please cite it using the
metadata from this file.
type: software
authors:
- given-names: Katrina
family-names: Eaton
email: katrina.eaton@ucsf.edu
affiliation: 'University of California, San Francisco'
identifiers:
- type: url
value: 'https://github.com/kaeaton/GSG-Kotlin'
description: >-
The Gene Feature Enumeration (GFE) Search
Generator
repository-code: 'https://github.com/kaeaton/GSG-Kotlin'
abstract: >-
There are currently 24,009 known variants (alleles)
of the Human Leukocyte Antigen genes, which are key
to transplant success or failure, with new alleles
being discovered and “named” every day. The current
names give very little information about the
structure of the proteins encoded by these genes,
and, in 2015, Dr. Steven Mack proposed a new naming
convention called Gene Feature Enumeration (GFE),
designed to create machine-readable names. New
tools are required to use the new GFE naming
convention, including the ability to (1) switch
between the allele names and the GFE names, (2)
search across GFE names, and (3) assign GFE names
to new alleles. In this thesis, I describe the GFE
Search Generator, a tool designed to make allele
identification using GFE names easier for research
purposes. This will enable better matches between
patients and donors for transplant purposes and
will assist in research about autoimmune diseases.
keywords:
- GFE
- Gene Feature Enumeration
- HLA
- Human Leukocyte Antigen
- KIR
- Killer Immunoglobulin-like Receptor
- Bioinformatics
license: GPL-3.0