diff --git a/changelog.d/changed/comment-cargo-lock.md b/changelog.d/changed/comment-cargo-lock.md
new file mode 100644
index 000000000..fa3351020
--- /dev/null
+++ b/changelog.d/changed/comment-cargo-lock.md
@@ -0,0 +1 @@
+- Allow Python-style comments in Cargo.lock files
diff --git a/src/reuse/comment.py b/src/reuse/comment.py
index 533bc3c0c..ad7b4f2db 100644
--- a/src/reuse/comment.py
+++ b/src/reuse/comment.py
@@ -875,7 +875,7 @@ class XQueryCommentStyle(CommentStyle):
     ".yarnrc": PythonCommentStyle,
     "ansible.cfg": PythonCommentStyle,
     "archive.sctxar": UncommentableCommentStyle,  # SuperCollider global archive
-    "Cargo.lock": UncommentableCommentStyle,
+    "Cargo.lock": PythonCommentStyle,
     "CMakeLists.txt": PythonCommentStyle,
     "CODEOWNERS": PythonCommentStyle,
     "configure.ac": M4CommentStyle,