Exploring Spacy .ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# <center>Dependency Parsing</center>\n",
    "- Spacy features a fast and accurate syntactic dependency parser along with API for navigating the tree\n",
    "\n",
    "- Parser also has sentence boundary detection\n",
    "\n",
    "- Parsed object shold be of [Doc](https://spacy.io/api/doc) type and can be checked using attribute ```doc.is_parsed``` which should return True\n",
    "\n",
    "\n",
    "--------------------------\n",
    "\n",
    "# <center>Noun chunks</center>\n",
    "\n",
    "- Noun chuncks are \"base noun phrases\". It has noun and the the words describing it. \n",
    "    **e.g: \"the lavish green grass\"**\n",
    "- It can be accessed in the doc by iterating over [doc.noun_chunks](https://spacy.io/api/doc#noun_chunks)\n",
    "\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {},
   "outputs": [],
   "source": [
    "from spacy import displacy"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [],
   "source": [
    "import spacy"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {},
   "outputs": [],
   "source": [
    "nlp = spacy.load(\"en_core_web_lg\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "[A phrase, another phrase]\n"
     ]
    }
   ],
   "source": [
    "# Noun Chunk\n",
    "\n",
    "doc = nlp(u\"A phrase with another phrase occurs.\")\n",
    "chunks = list(doc.noun_chunks)\n",
    "#assert chunks[0].text == u\"A phrase\"\n",
    "#assert chunks[1].text == u\"another phrase\"\n",
    "\n",
    "print(chunks)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Text --> Autonomous cars \n",
      " Root.Text --> cars \n",
      " Root.Dep_ --> nsubj \n",
      " Root.Head.Text --> shift \n",
      "\n",
      "Text --> insurance liability \n",
      " Root.Text --> liability \n",
      " Root.Dep_ --> dobj \n",
      " Root.Head.Text --> shift \n",
      "\n",
      "Text --> manufacturers \n",
      " Root.Text --> manufacturers \n",
      " Root.Dep_ --> pobj \n",
      " Root.Head.Text --> towards \n",
      "\n"
     ]
    }
   ],
   "source": [
    "# another example\n",
    "doc = nlp('Autonomous cars shift insurance liability towards manufacturers')\n",
    "\n",
    "for chunk in doc.noun_chunks:\n",
    "    print(\"Text -->\",chunk.text,\"\\n\",\"Root.Text -->\", chunk.root.text,\"\\n\",\"Root.Dep_ -->\", chunk.root.dep_,\"\\n\",\"Root.Head.Text -->\",chunk.root.head.text,\"\\n\")"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "**Text:** The original noun chunk text.\n",
    "\n",
    "**Root text:** The original text of the word connecting the noun chunk to the rest of the parse.\n",
    "\n",
    "**Root dep:** Dependency relation connecting the root to its head.\n",
    "\n",
    "**Root head text:** The text of the root token’s head."
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "**nsubj: nominal subject**\n",
    "\n",
    "A nominal subject(nsubj) is a nominal which is the syntactic subject and the prototype of a clause.\n",
    "\n",
    "It may be headed by a noun, or may be a pronoun or relative pronoun or as an adjactive\n",
    "\n",
    "\n",
    "In english, ***nsubj*** normally precedes the predicate that it depends on.\n",
    "\n",
    "More detail on [universal dependencies](https://universaldependencies.org/en/dep/nsubj.html)\n",
    "\n",
    "**dobj: direct object**\n",
    "\n",
    "The direct object of a VP is the noun phrase which is the (accusative) object of the verb.\n",
    "\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "object of preposition\n"
     ]
    }
   ],
   "source": [
    "print(spacy.explain('pobj'))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "nominal subject\n"
     ]
    }
   ],
   "source": [
    "print(spacy.explain('nsubj'))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "direct object\n"
     ]
    }
   ],
   "source": [
    "print(spacy.explain('dobj'))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {},
   "outputs": [],
   "source": [
    "# displacy.serve(doc, style='dep')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "metadata": {},
   "outputs": [],
   "source": [
    "# displacy.render(doc, style='dep')"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# <center>Navigating the parse tree</center>"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Spacy uses the term **head** and **child** to describe the words **conected by a single arc** in the dependency tree. \n",
    "\n",
    "\n",
    "> **Text:** The original token text.\n",
    "\n",
    "> **Dep:** The syntactic relation connecting child to head.\n",
    "\n",
    "> **Head text:** The original text of the token head.\n",
    "\n",
    "> **Head POS:** The part-of-speech tag of the token head.\n",
    "\n",
    "> **Children:** The immediate syntactic dependents of the token."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Token Text --> Token Dependency --> Token Head Text --> Token Head POS --> Token Children \n",
      "Autonomous --> amod --> cars --> NOUN --> []\n",
      "cars --> nsubj --> shift --> VERB --> [Autonomous]\n",
      "shift --> ROOT --> shift --> VERB --> [cars, liability, towards]\n",
      "insurance --> compound --> liability --> NOUN --> []\n",
      "liability --> dobj --> shift --> VERB --> [insurance]\n",
      "towards --> prep --> shift --> VERB --> [manufacturers]\n",
      "manufacturers --> pobj --> towards --> ADP --> []\n"
     ]
    }
   ],
   "source": [
    "print(\"Token Text --> Token Dependency --> Token Head Text --> Token Head POS --> Token Children \")\n",
    "for token in doc:\n",
    "    print(token.text,\"-->\",\n",
    "        token.dep_,\"-->\",\n",
    "         token.head.text,\"-->\",\n",
    "         token.head.pos_,\"-->\",\n",
    "         [child for child in token.children])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "'adjectival modifier'"
      ]
     },
     "execution_count": 12,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "spacy.explain(\"amod\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "metadata": {},
   "outputs": [
    {
     "data": {
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       "<text class=\"displacy-token\" fill=\"currentColor\" text-anchor=\"middle\" y=\"309.5\">\n",
       "    <tspan class=\"displacy-word\" fill=\"currentColor\" x=\"50\">Autonomous</tspan>\n",
       "    <tspan class=\"displacy-tag\" dy=\"2em\" fill=\"currentColor\" x=\"50\">ADJ</tspan>\n",
       "</text>\n",
       "\n",
       "<text class=\"displacy-token\" fill=\"currentColor\" text-anchor=\"middle\" y=\"309.5\">\n",
       "    <tspan class=\"displacy-word\" fill=\"currentColor\" x=\"225\">cars</tspan>\n",
       "    <tspan class=\"displacy-tag\" dy=\"2em\" fill=\"currentColor\" x=\"225\">NOUN</tspan>\n",
       "</text>\n",
       "\n",
       "<text class=\"displacy-token\" fill=\"currentColor\" text-anchor=\"middle\" y=\"309.5\">\n",
       "    <tspan class=\"displacy-word\" fill=\"currentColor\" x=\"400\">shift</tspan>\n",
       "    <tspan class=\"displacy-tag\" dy=\"2em\" fill=\"currentColor\" x=\"400\">VERB</tspan>\n",
       "</text>\n",
       "\n",
       "<text class=\"displacy-token\" fill=\"currentColor\" text-anchor=\"middle\" y=\"309.5\">\n",
       "    <tspan class=\"displacy-word\" fill=\"currentColor\" x=\"575\">insurance</tspan>\n",
       "    <tspan class=\"displacy-tag\" dy=\"2em\" fill=\"currentColor\" x=\"575\">NOUN</tspan>\n",
       "</text>\n",
       "\n",
       "<text class=\"displacy-token\" fill=\"currentColor\" text-anchor=\"middle\" y=\"309.5\">\n",
       "    <tspan class=\"displacy-word\" fill=\"currentColor\" x=\"750\">liability</tspan>\n",
       "    <tspan class=\"displacy-tag\" dy=\"2em\" fill=\"currentColor\" x=\"750\">NOUN</tspan>\n",
       "</text>\n",
       "\n",
       "<text class=\"displacy-token\" fill=\"currentColor\" text-anchor=\"middle\" y=\"309.5\">\n",
       "    <tspan class=\"displacy-word\" fill=\"currentColor\" x=\"925\">towards</tspan>\n",
       "    <tspan class=\"displacy-tag\" dy=\"2em\" fill=\"currentColor\" x=\"925\">ADP</tspan>\n",
       "</text>\n",
       "\n",
       "<text class=\"displacy-token\" fill=\"currentColor\" text-anchor=\"middle\" y=\"309.5\">\n",
       "    <tspan class=\"displacy-word\" fill=\"currentColor\" x=\"1100\">manufacturers</tspan>\n",
       "    <tspan class=\"displacy-tag\" dy=\"2em\" fill=\"currentColor\" x=\"1100\">NOUN</tspan>\n",
       "</text>\n",
       "\n",
       "<g class=\"displacy-arrow\">\n",
       "    <path class=\"displacy-arc\" id=\"arrow-e386f1d401d040be945d6eb3102bbeee-0-0\" stroke-width=\"2px\" d=\"M70,264.5 C70,177.0 215.0,177.0 215.0,264.5\" fill=\"none\" stroke=\"currentColor\"/>\n",
       "    <text dy=\"1.25em\" style=\"font-size: 0.8em; letter-spacing: 1px\">\n",
       "        <textPath xlink:href=\"#arrow-e386f1d401d040be945d6eb3102bbeee-0-0\" class=\"displacy-label\" startOffset=\"50%\" side=\"left\" fill=\"currentColor\" text-anchor=\"middle\">amod</textPath>\n",
       "    </text>\n",
       "    <path class=\"displacy-arrowhead\" d=\"M70,266.5 L62,254.5 78,254.5\" fill=\"currentColor\"/>\n",
       "</g>\n",
       "\n",
       "<g class=\"displacy-arrow\">\n",
       "    <path class=\"displacy-arc\" id=\"arrow-e386f1d401d040be945d6eb3102bbeee-0-1\" stroke-width=\"2px\" d=\"M245,264.5 C245,177.0 390.0,177.0 390.0,264.5\" fill=\"none\" stroke=\"currentColor\"/>\n",
       "    <text dy=\"1.25em\" style=\"font-size: 0.8em; letter-spacing: 1px\">\n",
       "        <textPath xlink:href=\"#arrow-e386f1d401d040be945d6eb3102bbeee-0-1\" class=\"displacy-label\" startOffset=\"50%\" side=\"left\" fill=\"currentColor\" text-anchor=\"middle\">nsubj</textPath>\n",
       "    </text>\n",
       "    <path class=\"displacy-arrowhead\" d=\"M245,266.5 L237,254.5 253,254.5\" fill=\"currentColor\"/>\n",
       "</g>\n",
       "\n",
       "<g class=\"displacy-arrow\">\n",
       "    <path class=\"displacy-arc\" id=\"arrow-e386f1d401d040be945d6eb3102bbeee-0-2\" stroke-width=\"2px\" d=\"M595,264.5 C595,177.0 740.0,177.0 740.0,264.5\" fill=\"none\" stroke=\"currentColor\"/>\n",
       "    <text dy=\"1.25em\" style=\"font-size: 0.8em; letter-spacing: 1px\">\n",
       "        <textPath xlink:href=\"#arrow-e386f1d401d040be945d6eb3102bbeee-0-2\" class=\"displacy-label\" startOffset=\"50%\" side=\"left\" fill=\"currentColor\" text-anchor=\"middle\">compound</textPath>\n",
       "    </text>\n",
       "    <path class=\"displacy-arrowhead\" d=\"M595,266.5 L587,254.5 603,254.5\" fill=\"currentColor\"/>\n",
       "</g>\n",
       "\n",
       "<g class=\"displacy-arrow\">\n",
       "    <path class=\"displacy-arc\" id=\"arrow-e386f1d401d040be945d6eb3102bbeee-0-3\" stroke-width=\"2px\" d=\"M420,264.5 C420,89.5 745.0,89.5 745.0,264.5\" fill=\"none\" stroke=\"currentColor\"/>\n",
       "    <text dy=\"1.25em\" style=\"font-size: 0.8em; letter-spacing: 1px\">\n",
       "        <textPath xlink:href=\"#arrow-e386f1d401d040be945d6eb3102bbeee-0-3\" class=\"displacy-label\" startOffset=\"50%\" side=\"left\" fill=\"currentColor\" text-anchor=\"middle\">dobj</textPath>\n",
       "    </text>\n",
       "    <path class=\"displacy-arrowhead\" d=\"M745.0,266.5 L753.0,254.5 737.0,254.5\" fill=\"currentColor\"/>\n",
       "</g>\n",
       "\n",
       "<g class=\"displacy-arrow\">\n",
       "    <path class=\"displacy-arc\" id=\"arrow-e386f1d401d040be945d6eb3102bbeee-0-4\" stroke-width=\"2px\" d=\"M420,264.5 C420,2.0 925.0,2.0 925.0,264.5\" fill=\"none\" stroke=\"currentColor\"/>\n",
       "    <text dy=\"1.25em\" style=\"font-size: 0.8em; letter-spacing: 1px\">\n",
       "        <textPath xlink:href=\"#arrow-e386f1d401d040be945d6eb3102bbeee-0-4\" class=\"displacy-label\" startOffset=\"50%\" side=\"left\" fill=\"currentColor\" text-anchor=\"middle\">prep</textPath>\n",
       "    </text>\n",
       "    <path class=\"displacy-arrowhead\" d=\"M925.0,266.5 L933.0,254.5 917.0,254.5\" fill=\"currentColor\"/>\n",
       "</g>\n",
       "\n",
       "<g class=\"displacy-arrow\">\n",
       "    <path class=\"displacy-arc\" id=\"arrow-e386f1d401d040be945d6eb3102bbeee-0-5\" stroke-width=\"2px\" d=\"M945,264.5 C945,177.0 1090.0,177.0 1090.0,264.5\" fill=\"none\" stroke=\"currentColor\"/>\n",
       "    <text dy=\"1.25em\" style=\"font-size: 0.8em; letter-spacing: 1px\">\n",
       "        <textPath xlink:href=\"#arrow-e386f1d401d040be945d6eb3102bbeee-0-5\" class=\"displacy-label\" startOffset=\"50%\" side=\"left\" fill=\"currentColor\" text-anchor=\"middle\">pobj</textPath>\n",
       "    </text>\n",
       "    <path class=\"displacy-arrowhead\" d=\"M1090.0,266.5 L1098.0,254.5 1082.0,254.5\" fill=\"currentColor\"/>\n",
       "</g>\n",
       "</svg>"
      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "displacy.render(doc, style=\"dep\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {},
   "outputs": [],
   "source": [
    "# Textacy is a wrapper on spacy \n",
    "import textacy"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {},
   "outputs": [],
   "source": [
    "doc_test = nlp(\"There was an old owl that lived in an oak. Everyday it saw incidents happening around it. It saw a boy helping an old man to carry a heavy basket yesterday. Today it saw a girl shouting at her mother. The more it saw the less it spoke. As it spoke less, it heard more. It heard people talking and telling stories. It heard a woman saying that an elephant jumped over a fence. It also heard a man saying that he had never made a mistake. The old owl had seen and heard about what happened to people. Some became better and some became worse. But the old owl had become wiser each and every day\") "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 16,
   "metadata": {},
   "outputs": [],
   "source": [
    "svo = textacy.extract.subject_verb_object_triples(doc_test)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 17,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "(There, was, owl)\n",
      "(boy, helping, man)\n",
      "(it, saw, less)\n",
      "(It, heard, man)\n",
      "(he, had never made, mistake)\n"
     ]
    }
   ],
   "source": [
    "for s in svo:\n",
    "    print(s)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# <center> Playing with trained spacy model and textacy</center>"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 18,
   "metadata": {},
   "outputs": [],
   "source": [
    "# Loading custom trained model\n",
    "nlp_custom = spacy.load(\"/home/ubuntu/Grakn/Spacy Play/spacy_en_core_web_lg\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "metadata": {},
   "outputs": [],
   "source": [
    "doc_custom = '''The BRAF inhibitor dabrafenib (Tafinlar(Â®)) and the MEK inhibitor trametinib (Mekinist(Â®)) are indicated, as monotherapy or in combination with each other, for the treatment of patients with unresectable or metastatic melanoma with a BRAF (V600) mutation. \n",
    "This article reviews the therapeutic efficacy and tolerability of combination treatment with dabrafenib and trametinib in this indication and summarizes relevant pharmacological data. \n",
    "Dabrafenib plus trametinib significantly prolonged progression-free survival (PFS) and overall survival (OS), improved objective response rates (ORRs) and preserved health-related quality of life (HR-QOL) to a greater extent than dabrafenib (in the double-blind COMBI-d study) and vemurafenib (in the open-label COMBI-v study) in two large, randomized, phase III studies in treatment-naÃ¯ve patients with unresectable or metastatic melanoma with BRAF (V600E/K) mutation. Limited treatment benefit with the combination was also seen in patients who had progressed on prior BRAF inhibitor therapy, as indicated by ORRs of â‰¤ 15Â % and stable disease in â‰¤ 50Â % of patients in small phase I and II studies. Combination therapy did not increase overall toxicity relative to dabrafenib or vemurafenib monotherapy, with most adverse events (AEs) mild or moderate in severity and generally manageable. Fewer skin-related AEs (e.g. cutaneous malignancies, hyperkeratinosis and hand-foot syndrome) were reported with combination therapy than with dabrafenib or vemurafenib, probably because of reduced paradoxical activation of the MAPK pathway. Thus, dabrafenib plus trametinib provides an important treatment option for patients with BRAF (V600) mutation-positive unresectable or metastatic melanoma.\n",
    "'''"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 20,
   "metadata": {},
   "outputs": [],
   "source": [
    "doc_nlp_custom = nlp_custom(doc_custom)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### <center>Extracting Subject Verb Object on the the medical doc</center>"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 21,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "(article, reviews, efficacy)\n",
      "(article, reviews, tolerability)\n",
      "(Dabrafenib, improved, response rates)\n",
      "(Dabrafenib, improved, patients)\n",
      "(Dabrafenib, improved, quality)\n",
      "(trametinib, improved, response rates)\n",
      "(trametinib, improved, patients)\n",
      "(trametinib, improved, quality)\n",
      "(survival, improved, response rates)\n",
      "(survival, improved, patients)\n",
      "(survival, improved, quality)\n",
      "(survival, improved, response rates)\n",
      "(survival, improved, patients)\n",
      "(survival, improved, quality)\n",
      "(Combination therapy, did not increase, toxicity)\n",
      "(dabrafenib, provides, treatment option)\n",
      "(trametinib, provides, treatment option)\n"
     ]
    }
   ],
   "source": [
    "for s in textacy.extract.subject_verb_object_triples(doc_nlp_custom):\n",
    "    print(s)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 22,
   "metadata": {},
   "outputs": [],
   "source": [
    "## Cusotm Subject Verb Object python file in the the same folder\n",
    "## Using for extracting subject verb object on th ebasis of conditions \n",
    "\n",
    "from subject_verb_object import findSVOs"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 23,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "('the therapeutic efficacy', 'review', 'This article')\n",
      "('this indication', 'review', 'This article')\n",
      "('tolerability', 'review', 'This article')\n",
      "('objective response rates ( ORRs', 'improve', 'Dabrafenib')\n",
      "('patients with unresectable melanoma with BRAF K ) mutation', 'improve', 'Dabrafenib')\n",
      "('a greater extent than in the blind d study', 'improve', 'Dabrafenib')\n",
      "('two III studies in -', 'improve', 'Dabrafenib')\n",
      "('ORRs )', 'improve', 'Dabrafenib')\n",
      "('quality of ( QOL )', 'improve', 'Dabrafenib')\n",
      "('vemurafenib ( in )', 'improve', 'Dabrafenib')\n",
      "('patients', 'see', 'Limited treatment benefit with the combination')\n",
      "('prior inhibitor therapy', 'progress', 'who')\n",
      "('overall toxicity relative', '!increase', 'Combination therapy')\n",
      "('most adverse events ( AEs mild in severity', '!increase', 'Combination therapy')\n",
      "('combination therapy', 'report', 'Fewer AEs malignancies')\n",
      "('reduced paradoxical activation of the MAPK pathway', 'report', 'Fewer AEs malignancies')\n",
      "('an important treatment option for patients with', 'provide', 'dabrafenib')\n"
     ]
    }
   ],
   "source": [
    "for i in findSVOs(doc_nlp_custom):\n",
    "    print(i)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 58,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "('There', 'was', 'an old owl')\n",
      "('a boy', 'helping', 'an old man')\n",
      "('an old man', 'carry', 'a heavy basket')\n",
      "('it', 'saw', 'the less')\n",
      "('people', 'talking', 'stories')\n",
      "('people', 'telling', 'stories')\n",
      "('It', 'heard', 'a man')\n",
      "('he', '!made', 'a mistake')\n"
     ]
    }
   ],
   "source": [
    "for i in findSVOs(doc_test):\n",
    "    print(i)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 25,
   "metadata": {},
   "outputs": [],
   "source": [
    "temp = findSVOs(doc_test)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 26,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[('There', 'was', 'an old owl'),\n",
       " ('a boy', 'helping', 'an old man'),\n",
       " ('an old man', 'carry', 'a heavy basket'),\n",
       " ('it', 'saw', 'the less'),\n",
       " ('people', 'talking', 'stories'),\n",
       " ('people', 'telling', 'stories'),\n",
       " ('It', 'heard', 'a man'),\n",
       " ('he', '!made', 'a mistake')]"
      ]
     },
     "execution_count": 26,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "temp"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 27,
   "metadata": {},
   "outputs": [],
   "source": [
    "textacy_svo = textacy.extract.subject_verb_object_triples(doc_test)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 28,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "(There, was, owl)\n",
      "(boy, helping, man)\n",
      "(it, saw, less)\n",
      "(It, heard, man)\n",
      "(he, had never made, mistake)\n"
     ]
    }
   ],
   "source": [
    "for s in textacy_svo:\n",
    "    print(s)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### <centre> Playing with mined Relation </centre>"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 118,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "(dabrafenib, provides, treatment option)\n",
      "(trametinib, provides, treatment option)\n"
     ]
    }
   ],
   "source": [
    "for s in textacy.extract.subject_verb_object_triples(nlp_custom('Thus, dabrafenib plus trametinib provides an important treatment option for patients with BRAF (V600) mutation-positive unresectable or metastatic melanoma.')):\n",
    "    print(s)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 120,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[('dabrafenib', 'provides', 'an important treatment option for patients with')]"
      ]
     },
     "execution_count": 120,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "findSVOs(nlp_custom('Thus, dabrafenib plus trametinib provides an important treatment option for patients with BRAF (V600) mutation-positive unresectable or metastatic melanoma.'))"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# <center>----</center>\n",
    "# <center>Corefrence</center>"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 29,
   "metadata": {},
   "outputs": [],
   "source": [
    "import spacy\n",
    "\n",
    "import neuralcoref\n",
    "\n",
    "\n",
    "nlp = spacy.load(\"en_core_web_lg\")\n",
    "\n",
    "#doc = nlp(\"There was an old owl that lived in an oak. Everyday it saw incidents happening around it. It saw a boy helping an old man to carry a heavy basket yesterday. Today it saw a girl shouting at her mother. The more it saw the less it spoke. As it spoke less, it heard more. It heard people talking and telling stories. It heard a woman saying that an elephant jumped over a fence. It also heard a man saying that he had never made a mistake. The old owl had seen and heard about what happened to people. Some became better and some became worse. But the old owl had become wiser each and every day\") \n",
    "\n",
    "coref = neuralcoref.NeuralCoref(nlp.vocab)\n",
    "\n",
    "nlp.add_pipe(coref, name='neuralcoref')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 59,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "True\n",
      "[an old owl that lived in an oak: [an old owl that lived in an oak, it, it, It, it, it, it, it, it, It, It, It, The old owl, the old owl], a girl: [a girl, her], a man saying that he had never made a mistake: [a man saying that he had never made a mistake, he]]\n"
     ]
    }
   ],
   "source": [
    "#nlp.add_pipe(neuralcoref)\n",
    "#doc = nlp(u'My sister has a dog. She loves him.')\n",
    "\n",
    "doc = nlp(\"There was an old owl that lived in an oak.\\\n",
    "Everyday it saw incidents happening around it.\\\n",
    "It saw a boy helping an old man to carry a heavy basket yesterday.\\\n",
    "Today it saw a girl shouting at her mother.\\\n",
    "The more it saw the less it spoke.\\\n",
    "As it spoke less, it heard more.\\\n",
    "It heard people talking and telling stories.\\\n",
    "It heard a woman saying that an elephant jumped over a fence.\\\n",
    "It also heard a man saying that he had never made a mistake.\\\n",
    "The old owl had seen and heard about what happened to people.\\\n",
    "Some became better and some became worse.\\\n",
    "But the old owl had become wiser each and every day\") \n",
    "\n",
    "\n",
    "print(doc._.has_coref)\n",
    "print(doc._.coref_clusters)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 62,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "[('tagger', <spacy.pipeline.pipes.Tagger object at 0x7fb2121d2128>), ('parser', <spacy.pipeline.pipes.DependencyParser object at 0x7fb211d87a08>), ('ner', <spacy.pipeline.pipes.EntityRecognizer object at 0x7fb211d87a68>), ('neuralcoref', <neuralcoref.neuralcoref.NeuralCoref object at 0x7fb2bc1ba9b0>)]\n"
     ]
    }
   ],
   "source": [
    "print(nlp.pipeline)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 61,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "an old owl that lived in an oak: [an old owl that lived in an oak, it, it, It, it, it, it, it, it, It, It, It, The old owl, the old owl] \n",
      "\n",
      "a girl: [a girl, her] \n",
      "\n",
      "a man saying that he had never made a mistake: [a man saying that he had never made a mistake, he] \n",
      "\n"
     ]
    }
   ],
   "source": [
    "for i in doc._.coref_clusters:\n",
    "    print(i,\"\\n\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 48,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "3"
      ]
     },
     "execution_count": 48,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "len(doc._.coref_clusters)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 56,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "an old owl that lived in an oak"
      ]
     },
     "execution_count": 56,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "doc._.coref_clusters[0].mentions[1]._.coref_cluster.main"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 57,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "False"
      ]
     },
     "execution_count": 57,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "doc._.coref_clusters\n",
    "doc._.coref_clusters[1].mentions\n",
    "doc._.coref_clusters[1].mentions[-1]\n",
    "doc._.coref_clusters[1].mentions[-1]._.coref_cluster.main\n",
    "\n",
    "token = doc[-1]\n",
    "token._.in_coref\n",
    "token._.coref_clusters\n",
    "\n",
    "span = doc[-1:]\n",
    "span._.is_coref\n",
    "#span._.coref_cluster.main\n",
    "#span._.coref_cluster.main._.coref_cluster"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 61,
   "metadata": {},
   "outputs": [],
   "source": [
    "# #coref = Coref()\n",
    "# clusters = coref.one_shot_coref(utterances=u\"She loves him.\", context=u\"My sister has a dog.\")\n",
    "# mentions = coref.get_mentions()\n",
    "# utterances = coref.get_utterances()\n",
    "# resolved_utterance_text = coref.get_resolved_utterances()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "# pip install neuralcoref"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 35,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "'4.0.0'"
      ]
     },
     "execution_count": 35,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "neuralcoref.__version__"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 16,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "There was an old owl that lived in an oak. Everyday it saw incidents happening around it. It saw a boy helping an old man to carry a heavy basket yesterday. Today it saw a girl shouting at her mother. The more it saw the less it spoke. As it spoke less, it heard more. It heard people talking and telling stories. It heard a woman saying that an elephant jumped over a fence. It also heard a man saying that he had never made a mistake. The old owl had seen and heard about what happened to people. Some became better and some became worse. But the old owl had become wiser each and every day"
      ]
     },
     "execution_count": 16,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "doc"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "False"
      ]
     },
     "execution_count": 15,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "doc._.has_coref"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {},
   "outputs": [],
   "source": [
    "# doc_nlp_custom._.has_coref"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {},
   "outputs": [],
   "source": [
    "doc._.coref_clusters"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "None\n"
     ]
    }
   ],
   "source": [
    "print(doc._.coref_clusters)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "# Corefrence witht Owl story\n",
    "import spacy\n",
    "import neuralcoref\n",
    "\n",
    "nlp = spacy.load(\"en_core_web_lg\")\n",
    "neuralcoref.add_to_pipe(nlp)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": []
  },
  {
   "cell_type": "code",
   "execution_count": 70,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "False"
      ]
     },
     "execution_count": 70,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "doc_nlp_custom._.has_coref"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# <center>Getting Sentence from a Spacy Doc </center>"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 116,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "0 --> The BRAF inhibitor dabrafenib (Tafinlar(Â®)) and the MEK inhibitor trametinib (Mekinist(Â®)) are indicated, as monotherapy or in combination with each other, for the treatment of patients with unresectable or metastatic melanoma with a BRAF (V600) mutation. \n",
      " \n",
      " sentiment --> 0.0 \n",
      "\n",
      "entity:\n",
      "BRAF 4 8 gene\n",
      "dabrafenib 19 29 drug\n",
      "MEK 53 56 protien\n",
      "trametinib 67 77 drug\n",
      "melanoma 220 228 diesease\n",
      "BRAF 236 240 gene\n",
      "V600 242 246 varient\n",
      "\n",
      " Token:\n",
      "The the DET DT det Xxx True True\n",
      "BRAF BRAF PROPN NNP compound XXXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "dabrafenib dabrafenib NOUN NN nsubjpass xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "Tafinlar(Â Tafinlar(Â PROPN NNP compound Xxxxx(X False False\n",
      "® ® PROPN NNP appos ® False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "the the DET DT det xxx True True\n",
      "MEK MEK PROPN NNP compound XXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "Mekinist(Â Mekinist(Â PROPN NNP compound Xxxxx(X False False\n",
      "® ® PROPN NNP appos ® False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "are be VERB VBP auxpass xxx True True\n",
      "indicated indicate VERB VBN ROOT xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "as as ADP IN advmod xx True True\n",
      "monotherapy monotherapy ADV RB advmod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "in in ADP IN advcl xx True True\n",
      "combination combination NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "each each DET DT det xxxx True True\n",
      "other other ADJ JJ pobj xxxx True True\n",
      ", , PUNCT , punct , False False\n",
      "for for ADP IN conj xxx True True\n",
      "the the DET DT det xxx True True\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "a a DET DT det x True True\n",
      "BRAF BRAF PROPN NNP nmod XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600 V600 PROPN NNP subtok Xddd False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "This this DET DT det Xxxx True True\n",
      "article article NOUN NN nsubj xxxx True False\n",
      "reviews review VERB VBZ ROOT xxxx True False\n",
      "the the DET DT det xxx True True\n",
      "therapeutic therapeutic ADJ JJ amod xxxx True False\n",
      "efficacy efficacy NOUN NN dobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "tolerability tolerability NOUN NN conj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "combination combination NOUN NN compound xxxx True False\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "this this DET DT det xxxx True True\n",
      "indication indication NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "summarizes summarize VERB VBZ conj xxxx True False\n",
      "relevant relevant ADJ JJ amod xxxx True False\n",
      "pharmacological pharmacological ADJ JJ amod xxxx True False\n",
      "data datum NOUN NNS dobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "Dabrafenib Dabrafenib PROPN NNP nsubj Xxxxx True False\n",
      "plus plus CCONJ CC cc xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "significantly significantly ADV RB advmod xxxx True False\n",
      "prolonged prolong VERB VBD amod xxxx True False\n",
      "progression progression NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "free free ADJ JJ amod xxxx True False\n",
      "survival survival NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "PFS PFS PROPN NNP appos XXX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "overall overall ADJ JJ amod xxxx True False\n",
      "survival survival NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "OS OS PROPN NNP appos XX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ", , PUNCT , punct , False False\n",
      "improved improve VERB VBN ROOT xxxx True False\n",
      "objective objective ADJ JJ amod xxxx True False\n",
      "response response NOUN NN compound xxxx True False\n",
      "rates rate NOUN NNS dobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "ORRs orr NOUN NNS appos XXXx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "preserved preserve VERB VBN amod xxxx True False\n",
      "health health NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "related relate VERB VBN amod xxxx True False\n",
      "quality quality NOUN NN conj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "life life NOUN NN pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "HR HR PROPN NNP compound XX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "QOL QOL PROPN NNP appos XXX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "to to ADP IN prep xx True True\n",
      "a a DET DT det x True True\n",
      "greater great ADJ JJR amod xxxx True False\n",
      "extent extent NOUN NN pobj xxxx True False\n",
      "than than ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "in in ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "double double ADJ JJ amod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "blind blind ADJ JJ amod xxxx True False\n",
      "COMBI combi NOUN NN compound XXXX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "d d ADJ JJ compound x True False\n",
      "study study NOUN NN pobj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "in in ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "open open ADJ JJ amod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "label label NOUN NN compound xxxx True False\n",
      "COMBI COMBI PROPN NNP compound XXXX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "v v PROPN NNP compound x True False\n",
      "study study NOUN NN pobj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "in in ADP IN prep xx True True\n",
      "two two NUM CD nummod xxx True True\n",
      "large large ADJ JJ amod xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "randomized randomize VERB VBN conj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "phase phase NOUN NN compound xxxx True False\n",
      "III iii NUM CD compound XXX True False\n",
      "studies study NOUN NNS pobj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "naÃ¯ve naã¯ve NUM CD punct xxX¯xx False False\n",
      "patients patient NOUN NNS dobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "BRAF BRAF PROPN NNP nmod XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600E V600E PROPN NNP nmod XdddX False False\n",
      "/ / SYM SYM punct / False False\n",
      "K K PROPN NNP nmod X True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Limited limited ADJ JJ amod Xxxxx True False\n",
      "treatment treatment NOUN NN compound xxxx True False\n",
      "benefit benefit NOUN NN nsubjpass xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "the the DET DT det xxx True True\n",
      "combination combination NOUN NN pobj xxxx True False\n",
      "was be VERB VBD auxpass xxx True True\n",
      "also also ADV RB advmod xxxx True True\n",
      "seen see VERB VBN ROOT xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "who who PRON WP nsubj xxx True True\n",
      "had have VERB VBD aux xxx True True\n",
      "progressed progress VERB VBN relcl xxxx True False\n",
      "on on ADP IN prep xx True True\n",
      "prior prior ADJ JJ amod xxxx True False\n",
      "BRAF BRAF PROPN NNP compound XXXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "therapy therapy NOUN NN pobj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "as as ADP IN mark xx True True\n",
      "indicated indicate VERB VBN advcl xxxx True False\n",
      "by by ADP IN agent xx True True\n",
      "ORRs orr NOUN NNS pobj XXXx True False\n",
      "of of ADP IN prep xx True True\n",
      "â‰¤ â‰¤ SYM $ nmod x‰¤ False False\n",
      "15Â 15â NUM CD nummod ddX False False\n",
      "% % NOUN NN pobj % False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "stable stable ADJ JJ amod xxxx True False\n",
      "disease disease NOUN NN conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "â‰¤ â‰¤ SYM $ pobj x‰¤ False False\n",
      "50Â 50â NUM CD nummod ddX False False\n",
      "% % NOUN NN dobj % False False\n",
      "of of ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "small small ADJ JJ amod xxxx True False\n",
      "phase phase NOUN NN nmod xxxx True False\n",
      "I -PRON- PRON PRP nmod X True True\n",
      "and and CCONJ CC cc xxx True True\n",
      "II II PROPN NNP conj XX True False\n",
      "studies study NOUN NNS pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Combination combination NOUN NN compound Xxxxx True False\n",
      "therapy therapy NOUN NN nsubj xxxx True False\n",
      "did do VERB VBD aux xxx True True\n",
      "not not ADV RB neg xxx True True\n",
      "increase increase VERB VB ROOT xxxx True False\n",
      "overall overall ADJ JJ amod xxxx True False\n",
      "toxicity toxicity NOUN NN dobj xxxx True False\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "relative relative ADJ JJ amod xxxx True False\n",
      "to to ADP IN prep xx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      "monotherapy monotherapy NOUN NN advmod xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "with with ADP IN prep xxxx True True\n",
      "most most ADJ JJS amod xxxx True True\n",
      "adverse adverse ADJ JJ amod xxxx True False\n",
      "events event NOUN NNS pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "AEs AEs PROPN NNP appos XXx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mild mild ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "moderate moderate ADJ JJ conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "severity severity NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "generally generally ADV RB advmod xxxx True False\n",
      "manageable manageable ADJ JJ conj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Fewer few ADJ JJR amod Xxxxx True False\n",
      "skin skin NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "related relate VERB VBN amod xxxx True False\n",
      "AEs ae NOUN NNS nsubjpass XXx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "e.g. e.g. X FW amod x.x. False False\n",
      "cutaneous cutaneous ADJ JJ amod xxxx True False\n",
      "malignancies malignancy NOUN NNS appos xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "hyperkeratinosis hyperkeratinosis NOUN NN conj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "hand hand NOUN NN compound xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "foot foot NOUN NN compound xxxx True False\n",
      "syndrome syndrome NOUN NN conj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "were be VERB VBD auxpass xxxx True True\n",
      "reported report VERB VBN ROOT xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "combination combination NOUN NN compound xxxx True False\n",
      "therapy therapy NOUN NN pobj xxxx True False\n",
      "than than ADP IN prep xxxx True True\n",
      "with with ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "probably probably ADV RB advmod xxxx True False\n",
      "because because ADP IN prep xxxx True True\n",
      "of of ADP IN pcomp xx True True\n",
      "reduced reduced ADJ JJ amod xxxx True False\n",
      "paradoxical paradoxical ADJ JJ amod xxxx True False\n",
      "activation activation NOUN NN pobj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "MAPK MAPK PROPN NNP compound XXXX True False\n",
      "pathway pathway NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Thus thus ADV RB advmod Xxxx True True\n",
      ", , PUNCT , punct , False False\n",
      "dabrafenib dabrafenib NOUN NN nsubj xxxx True False\n",
      "plus plus CCONJ CC cc xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "provides provide VERB VBZ ROOT xxxx True False\n",
      "an an DET DT det xx True True\n",
      "important important ADJ JJ amod xxxx True False\n",
      "treatment treatment NOUN NN compound xxxx True False\n",
      "option option NOUN NN dobj xxxx True False\n",
      "for for ADP IN prep xxx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "BRAF BRAF PROPN NNP pobj XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600 V600 PROPN NNP subtok Xddd False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "positive positive ADJ JJ amod xxxx True False\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN appos xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "1 --> This article reviews the therapeutic efficacy and tolerability of combination treatment with dabrafenib and trametinib in this indication and summarizes relevant pharmacological data. \n",
      " \n",
      " sentiment --> 0.0 \n",
      "\n",
      "entity:\n",
      "trametinib 367 377 drug\n",
      "\n",
      " Token:\n",
      "The the DET DT det Xxx True True\n",
      "BRAF BRAF PROPN NNP compound XXXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "dabrafenib dabrafenib NOUN NN nsubjpass xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "Tafinlar(Â Tafinlar(Â PROPN NNP compound Xxxxx(X False False\n",
      "® ® PROPN NNP appos ® False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "the the DET DT det xxx True True\n",
      "MEK MEK PROPN NNP compound XXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "Mekinist(Â Mekinist(Â PROPN NNP compound Xxxxx(X False False\n",
      "® ® PROPN NNP appos ® False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "are be VERB VBP auxpass xxx True True\n",
      "indicated indicate VERB VBN ROOT xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "as as ADP IN advmod xx True True\n",
      "monotherapy monotherapy ADV RB advmod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "in in ADP IN advcl xx True True\n",
      "combination combination NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "each each DET DT det xxxx True True\n",
      "other other ADJ JJ pobj xxxx True True\n",
      ", , PUNCT , punct , False False\n",
      "for for ADP IN conj xxx True True\n",
      "the the DET DT det xxx True True\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "a a DET DT det x True True\n",
      "BRAF BRAF PROPN NNP nmod XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600 V600 PROPN NNP subtok Xddd False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "This this DET DT det Xxxx True True\n",
      "article article NOUN NN nsubj xxxx True False\n",
      "reviews review VERB VBZ ROOT xxxx True False\n",
      "the the DET DT det xxx True True\n",
      "therapeutic therapeutic ADJ JJ amod xxxx True False\n",
      "efficacy efficacy NOUN NN dobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "tolerability tolerability NOUN NN conj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "combination combination NOUN NN compound xxxx True False\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "this this DET DT det xxxx True True\n",
      "indication indication NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "summarizes summarize VERB VBZ conj xxxx True False\n",
      "relevant relevant ADJ JJ amod xxxx True False\n",
      "pharmacological pharmacological ADJ JJ amod xxxx True False\n",
      "data datum NOUN NNS dobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "Dabrafenib Dabrafenib PROPN NNP nsubj Xxxxx True False\n",
      "plus plus CCONJ CC cc xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "significantly significantly ADV RB advmod xxxx True False\n",
      "prolonged prolong VERB VBD amod xxxx True False\n",
      "progression progression NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "free free ADJ JJ amod xxxx True False\n",
      "survival survival NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "PFS PFS PROPN NNP appos XXX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "overall overall ADJ JJ amod xxxx True False\n",
      "survival survival NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "OS OS PROPN NNP appos XX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ", , PUNCT , punct , False False\n",
      "improved improve VERB VBN ROOT xxxx True False\n",
      "objective objective ADJ JJ amod xxxx True False\n",
      "response response NOUN NN compound xxxx True False\n",
      "rates rate NOUN NNS dobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "ORRs orr NOUN NNS appos XXXx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "preserved preserve VERB VBN amod xxxx True False\n",
      "health health NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "related relate VERB VBN amod xxxx True False\n",
      "quality quality NOUN NN conj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "life life NOUN NN pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "HR HR PROPN NNP compound XX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "QOL QOL PROPN NNP appos XXX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "to to ADP IN prep xx True True\n",
      "a a DET DT det x True True\n",
      "greater great ADJ JJR amod xxxx True False\n",
      "extent extent NOUN NN pobj xxxx True False\n",
      "than than ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "in in ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "double double ADJ JJ amod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "blind blind ADJ JJ amod xxxx True False\n",
      "COMBI combi NOUN NN compound XXXX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "d d ADJ JJ compound x True False\n",
      "study study NOUN NN pobj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "in in ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "open open ADJ JJ amod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "label label NOUN NN compound xxxx True False\n",
      "COMBI COMBI PROPN NNP compound XXXX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "v v PROPN NNP compound x True False\n",
      "study study NOUN NN pobj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "in in ADP IN prep xx True True\n",
      "two two NUM CD nummod xxx True True\n",
      "large large ADJ JJ amod xxxx True False\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      ", , PUNCT , punct , False False\n",
      "randomized randomize VERB VBN conj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "phase phase NOUN NN compound xxxx True False\n",
      "III iii NUM CD compound XXX True False\n",
      "studies study NOUN NNS pobj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "naÃ¯ve naã¯ve NUM CD punct xxX¯xx False False\n",
      "patients patient NOUN NNS dobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "BRAF BRAF PROPN NNP nmod XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600E V600E PROPN NNP nmod XdddX False False\n",
      "/ / SYM SYM punct / False False\n",
      "K K PROPN NNP nmod X True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Limited limited ADJ JJ amod Xxxxx True False\n",
      "treatment treatment NOUN NN compound xxxx True False\n",
      "benefit benefit NOUN NN nsubjpass xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "the the DET DT det xxx True True\n",
      "combination combination NOUN NN pobj xxxx True False\n",
      "was be VERB VBD auxpass xxx True True\n",
      "also also ADV RB advmod xxxx True True\n",
      "seen see VERB VBN ROOT xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "who who PRON WP nsubj xxx True True\n",
      "had have VERB VBD aux xxx True True\n",
      "progressed progress VERB VBN relcl xxxx True False\n",
      "on on ADP IN prep xx True True\n",
      "prior prior ADJ JJ amod xxxx True False\n",
      "BRAF BRAF PROPN NNP compound XXXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "therapy therapy NOUN NN pobj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "as as ADP IN mark xx True True\n",
      "indicated indicate VERB VBN advcl xxxx True False\n",
      "by by ADP IN agent xx True True\n",
      "ORRs orr NOUN NNS pobj XXXx True False\n",
      "of of ADP IN prep xx True True\n",
      "â‰¤ â‰¤ SYM $ nmod x‰¤ False False\n",
      "15Â 15â NUM CD nummod ddX False False\n",
      "% % NOUN NN pobj % False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "stable stable ADJ JJ amod xxxx True False\n",
      "disease disease NOUN NN conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "â‰¤ â‰¤ SYM $ pobj x‰¤ False False\n",
      "50Â 50â NUM CD nummod ddX False False\n",
      "% % NOUN NN dobj % False False\n",
      "of of ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "small small ADJ JJ amod xxxx True False\n",
      "phase phase NOUN NN nmod xxxx True False\n",
      "I -PRON- PRON PRP nmod X True True\n",
      "and and CCONJ CC cc xxx True True\n",
      "II II PROPN NNP conj XX True False\n",
      "studies study NOUN NNS pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Combination combination NOUN NN compound Xxxxx True False\n",
      "therapy therapy NOUN NN nsubj xxxx True False\n",
      "did do VERB VBD aux xxx True True\n",
      "not not ADV RB neg xxx True True\n",
      "increase increase VERB VB ROOT xxxx True False\n",
      "overall overall ADJ JJ amod xxxx True False\n",
      "toxicity toxicity NOUN NN dobj xxxx True False\n",
      "relative relative ADJ JJ amod xxxx True False\n",
      "to to ADP IN prep xx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      "monotherapy monotherapy NOUN NN advmod xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "with with ADP IN prep xxxx True True\n",
      "most most ADJ JJS amod xxxx True True\n",
      "adverse adverse ADJ JJ amod xxxx True False\n",
      "events event NOUN NNS pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "AEs AEs PROPN NNP appos XXx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mild mild ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "moderate moderate ADJ JJ conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "severity severity NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "generally generally ADV RB advmod xxxx True False\n",
      "manageable manageable ADJ JJ conj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Fewer few ADJ JJR amod Xxxxx True False\n",
      "skin skin NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "related relate VERB VBN amod xxxx True False\n",
      "AEs ae NOUN NNS nsubjpass XXx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "e.g. e.g. X FW amod x.x. False False\n",
      "cutaneous cutaneous ADJ JJ amod xxxx True False\n",
      "malignancies malignancy NOUN NNS appos xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "hyperkeratinosis hyperkeratinosis NOUN NN conj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "hand hand NOUN NN compound xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "foot foot NOUN NN compound xxxx True False\n",
      "syndrome syndrome NOUN NN conj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "were be VERB VBD auxpass xxxx True True\n",
      "reported report VERB VBN ROOT xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "combination combination NOUN NN compound xxxx True False\n",
      "therapy therapy NOUN NN pobj xxxx True False\n",
      "than than ADP IN prep xxxx True True\n",
      "with with ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "probably probably ADV RB advmod xxxx True False\n",
      "because because ADP IN prep xxxx True True\n",
      "of of ADP IN pcomp xx True True\n",
      "reduced reduced ADJ JJ amod xxxx True False\n",
      "paradoxical paradoxical ADJ JJ amod xxxx True False\n",
      "activation activation NOUN NN pobj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "MAPK MAPK PROPN NNP compound XXXX True False\n",
      "pathway pathway NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Thus thus ADV RB advmod Xxxx True True\n",
      ", , PUNCT , punct , False False\n",
      "dabrafenib dabrafenib NOUN NN nsubj xxxx True False\n",
      "plus plus CCONJ CC cc xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "provides provide VERB VBZ ROOT xxxx True False\n",
      "an an DET DT det xx True True\n",
      "important important ADJ JJ amod xxxx True False\n",
      "treatment treatment NOUN NN compound xxxx True False\n",
      "option option NOUN NN dobj xxxx True False\n",
      "for for ADP IN prep xxx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "BRAF BRAF PROPN NNP pobj XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600 V600 PROPN NNP subtok Xddd False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "positive positive ADJ JJ amod xxxx True False\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN appos xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "2 --> Dabrafenib plus trametinib significantly prolonged progression-free survival (PFS) and overall survival (OS), improved objective response rates (ORRs) and preserved health-related quality of life (HR-QOL) to a greater extent than dabrafenib (in the double-blind COMBI-d study) and vemurafenib (in the open-label COMBI-v study) in two large, randomized, phase III studies in treatment-naÃ¯ve patients with unresectable or metastatic melanoma with BRAF (V600E/K) mutation. \n",
      " sentiment --> 0.0 \n",
      "\n",
      "entity:\n",
      "Dabrafenib 444 454 drug\n",
      "trametinib 460 470 drug\n",
      "melanoma 876 884 diesease\n",
      "BRAF 890 894 gene\n",
      "V600E/K 896 903 varient\n",
      "\n",
      " Token:\n",
      "The the DET DT det Xxx True True\n",
      "BRAF BRAF PROPN NNP compound XXXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "dabrafenib dabrafenib NOUN NN nsubjpass xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "Tafinlar(Â Tafinlar(Â PROPN NNP compound Xxxxx(X False False\n",
      "® ® PROPN NNP appos ® False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "the the DET DT det xxx True True\n",
      "MEK MEK PROPN NNP compound XXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "Mekinist(Â Mekinist(Â PROPN NNP compound Xxxxx(X False False\n",
      "® ® PROPN NNP appos ® False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "are be VERB VBP auxpass xxx True True\n",
      "indicated indicate VERB VBN ROOT xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "as as ADP IN advmod xx True True\n",
      "monotherapy monotherapy ADV RB advmod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "in in ADP IN advcl xx True True\n",
      "combination combination NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "each each DET DT det xxxx True True\n",
      "other other ADJ JJ pobj xxxx True True\n",
      ", , PUNCT , punct , False False\n",
      "for for ADP IN conj xxx True True\n",
      "the the DET DT det xxx True True\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "a a DET DT det x True True\n",
      "BRAF BRAF PROPN NNP nmod XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600 V600 PROPN NNP subtok Xddd False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "This this DET DT det Xxxx True True\n",
      "article article NOUN NN nsubj xxxx True False\n",
      "reviews review VERB VBZ ROOT xxxx True False\n",
      "the the DET DT det xxx True True\n",
      "therapeutic therapeutic ADJ JJ amod xxxx True False\n",
      "efficacy efficacy NOUN NN dobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "tolerability tolerability NOUN NN conj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "combination combination NOUN NN compound xxxx True False\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "this this DET DT det xxxx True True\n",
      "indication indication NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "summarizes summarize VERB VBZ conj xxxx True False\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "relevant relevant ADJ JJ amod xxxx True False\n",
      "pharmacological pharmacological ADJ JJ amod xxxx True False\n",
      "data datum NOUN NNS dobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "Dabrafenib Dabrafenib PROPN NNP nsubj Xxxxx True False\n",
      "plus plus CCONJ CC cc xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "significantly significantly ADV RB advmod xxxx True False\n",
      "prolonged prolong VERB VBD amod xxxx True False\n",
      "progression progression NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "free free ADJ JJ amod xxxx True False\n",
      "survival survival NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "PFS PFS PROPN NNP appos XXX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "overall overall ADJ JJ amod xxxx True False\n",
      "survival survival NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "OS OS PROPN NNP appos XX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ", , PUNCT , punct , False False\n",
      "improved improve VERB VBN ROOT xxxx True False\n",
      "objective objective ADJ JJ amod xxxx True False\n",
      "response response NOUN NN compound xxxx True False\n",
      "rates rate NOUN NNS dobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "ORRs orr NOUN NNS appos XXXx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "preserved preserve VERB VBN amod xxxx True False\n",
      "health health NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "related relate VERB VBN amod xxxx True False\n",
      "quality quality NOUN NN conj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "life life NOUN NN pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "HR HR PROPN NNP compound XX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "QOL QOL PROPN NNP appos XXX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "to to ADP IN prep xx True True\n",
      "a a DET DT det x True True\n",
      "greater great ADJ JJR amod xxxx True False\n",
      "extent extent NOUN NN pobj xxxx True False\n",
      "than than ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "in in ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "double double ADJ JJ amod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "blind blind ADJ JJ amod xxxx True False\n",
      "COMBI combi NOUN NN compound XXXX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "d d ADJ JJ compound x True False\n",
      "study study NOUN NN pobj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "in in ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "open open ADJ JJ amod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "label label NOUN NN compound xxxx True False\n",
      "COMBI COMBI PROPN NNP compound XXXX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "v v PROPN NNP compound x True False\n",
      "study study NOUN NN pobj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "in in ADP IN prep xx True True\n",
      "two two NUM CD nummod xxx True True\n",
      "large large ADJ JJ amod xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "randomized randomize VERB VBN conj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "phase phase NOUN NN compound xxxx True False\n",
      "III iii NUM CD compound XXX True False\n",
      "studies study NOUN NNS pobj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "naÃ¯ve naã¯ve NUM CD punct xxX¯xx False False\n",
      "patients patient NOUN NNS dobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "BRAF BRAF PROPN NNP nmod XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600E V600E PROPN NNP nmod XdddX False False\n",
      "/ / SYM SYM punct / False False\n",
      "K K PROPN NNP nmod X True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Limited limited ADJ JJ amod Xxxxx True False\n",
      "treatment treatment NOUN NN compound xxxx True False\n",
      "benefit benefit NOUN NN nsubjpass xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "the the DET DT det xxx True True\n",
      "combination combination NOUN NN pobj xxxx True False\n",
      "was be VERB VBD auxpass xxx True True\n",
      "also also ADV RB advmod xxxx True True\n",
      "seen see VERB VBN ROOT xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "who who PRON WP nsubj xxx True True\n",
      "had have VERB VBD aux xxx True True\n",
      "progressed progress VERB VBN relcl xxxx True False\n",
      "on on ADP IN prep xx True True\n",
      "prior prior ADJ JJ amod xxxx True False\n",
      "BRAF BRAF PROPN NNP compound XXXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "therapy therapy NOUN NN pobj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "as as ADP IN mark xx True True\n",
      "indicated indicate VERB VBN advcl xxxx True False\n",
      "by by ADP IN agent xx True True\n",
      "ORRs orr NOUN NNS pobj XXXx True False\n",
      "of of ADP IN prep xx True True\n",
      "â‰¤ â‰¤ SYM $ nmod x‰¤ False False\n",
      "15Â 15â NUM CD nummod ddX False False\n",
      "% % NOUN NN pobj % False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "stable stable ADJ JJ amod xxxx True False\n",
      "disease disease NOUN NN conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "â‰¤ â‰¤ SYM $ pobj x‰¤ False False\n",
      "50Â 50â NUM CD nummod ddX False False\n",
      "% % NOUN NN dobj % False False\n",
      "of of ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "small small ADJ JJ amod xxxx True False\n",
      "phase phase NOUN NN nmod xxxx True False\n",
      "I -PRON- PRON PRP nmod X True True\n",
      "and and CCONJ CC cc xxx True True\n",
      "II II PROPN NNP conj XX True False\n",
      "studies study NOUN NNS pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Combination combination NOUN NN compound Xxxxx True False\n",
      "therapy therapy NOUN NN nsubj xxxx True False\n",
      "did do VERB VBD aux xxx True True\n",
      "not not ADV RB neg xxx True True\n",
      "increase increase VERB VB ROOT xxxx True False\n",
      "overall overall ADJ JJ amod xxxx True False\n",
      "toxicity toxicity NOUN NN dobj xxxx True False\n",
      "relative relative ADJ JJ amod xxxx True False\n",
      "to to ADP IN prep xx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      "monotherapy monotherapy NOUN NN advmod xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "with with ADP IN prep xxxx True True\n",
      "most most ADJ JJS amod xxxx True True\n",
      "adverse adverse ADJ JJ amod xxxx True False\n",
      "events event NOUN NNS pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "AEs AEs PROPN NNP appos XXx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mild mild ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "moderate moderate ADJ JJ conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "severity severity NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "generally generally ADV RB advmod xxxx True False\n",
      "manageable manageable ADJ JJ conj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Fewer few ADJ JJR amod Xxxxx True False\n",
      "skin skin NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "related relate VERB VBN amod xxxx True False\n",
      "AEs ae NOUN NNS nsubjpass XXx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "e.g. e.g. X FW amod x.x. False False\n",
      "cutaneous cutaneous ADJ JJ amod xxxx True False\n",
      "malignancies malignancy NOUN NNS appos xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "hyperkeratinosis hyperkeratinosis NOUN NN conj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "hand hand NOUN NN compound xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "foot foot NOUN NN compound xxxx True False\n",
      "syndrome syndrome NOUN NN conj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "were be VERB VBD auxpass xxxx True True\n",
      "reported report VERB VBN ROOT xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "combination combination NOUN NN compound xxxx True False\n",
      "therapy therapy NOUN NN pobj xxxx True False\n",
      "than than ADP IN prep xxxx True True\n",
      "with with ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "probably probably ADV RB advmod xxxx True False\n",
      "because because ADP IN prep xxxx True True\n",
      "of of ADP IN pcomp xx True True\n",
      "reduced reduced ADJ JJ amod xxxx True False\n",
      "paradoxical paradoxical ADJ JJ amod xxxx True False\n",
      "activation activation NOUN NN pobj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "MAPK MAPK PROPN NNP compound XXXX True False\n",
      "pathway pathway NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Thus thus ADV RB advmod Xxxx True True\n",
      ", , PUNCT , punct , False False\n",
      "dabrafenib dabrafenib NOUN NN nsubj xxxx True False\n",
      "plus plus CCONJ CC cc xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "provides provide VERB VBZ ROOT xxxx True False\n",
      "an an DET DT det xx True True\n",
      "important important ADJ JJ amod xxxx True False\n",
      "treatment treatment NOUN NN compound xxxx True False\n",
      "option option NOUN NN dobj xxxx True False\n",
      "for for ADP IN prep xxx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "BRAF BRAF PROPN NNP pobj XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600 V600 PROPN NNP subtok Xddd False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "positive positive ADJ JJ amod xxxx True False\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "melanoma melanoma NOUN NN appos xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "3 --> Limited treatment benefit with the combination was also seen in patients who had progressed on prior BRAF inhibitor therapy, as indicated by ORRs of â‰¤ 15Â % and stable disease in â‰¤ 50Â % of patients in small phase I and II studies. \n",
      " sentiment --> 0.0 \n",
      "\n",
      "entity:\n",
      "\n",
      " Token:\n",
      "The the DET DT det Xxx True True\n",
      "BRAF BRAF PROPN NNP compound XXXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "dabrafenib dabrafenib NOUN NN nsubjpass xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "Tafinlar(Â Tafinlar(Â PROPN NNP compound Xxxxx(X False False\n",
      "® ® PROPN NNP appos ® False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "the the DET DT det xxx True True\n",
      "MEK MEK PROPN NNP compound XXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "Mekinist(Â Mekinist(Â PROPN NNP compound Xxxxx(X False False\n",
      "® ® PROPN NNP appos ® False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "are be VERB VBP auxpass xxx True True\n",
      "indicated indicate VERB VBN ROOT xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "as as ADP IN advmod xx True True\n",
      "monotherapy monotherapy ADV RB advmod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "in in ADP IN advcl xx True True\n",
      "combination combination NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "each each DET DT det xxxx True True\n",
      "other other ADJ JJ pobj xxxx True True\n",
      ", , PUNCT , punct , False False\n",
      "for for ADP IN conj xxx True True\n",
      "the the DET DT det xxx True True\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "a a DET DT det x True True\n",
      "BRAF BRAF PROPN NNP nmod XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600 V600 PROPN NNP subtok Xddd False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "This this DET DT det Xxxx True True\n",
      "article article NOUN NN nsubj xxxx True False\n",
      "reviews review VERB VBZ ROOT xxxx True False\n",
      "the the DET DT det xxx True True\n",
      "therapeutic therapeutic ADJ JJ amod xxxx True False\n",
      "efficacy efficacy NOUN NN dobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "tolerability tolerability NOUN NN conj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "combination combination NOUN NN compound xxxx True False\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "this this DET DT det xxxx True True\n",
      "indication indication NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "summarizes summarize VERB VBZ conj xxxx True False\n",
      "relevant relevant ADJ JJ amod xxxx True False\n",
      "pharmacological pharmacological ADJ JJ amod xxxx True False\n",
      "data datum NOUN NNS dobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "Dabrafenib Dabrafenib PROPN NNP nsubj Xxxxx True False\n",
      "plus plus CCONJ CC cc xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "significantly significantly ADV RB advmod xxxx True False\n",
      "prolonged prolong VERB VBD amod xxxx True False\n",
      "progression progression NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "free free ADJ JJ amod xxxx True False\n",
      "survival survival NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "PFS PFS PROPN NNP appos XXX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "overall overall ADJ JJ amod xxxx True False\n",
      "survival survival NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "OS OS PROPN NNP appos XX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ", , PUNCT , punct , False False\n",
      "improved improve VERB VBN ROOT xxxx True False\n",
      "objective objective ADJ JJ amod xxxx True False\n",
      "response response NOUN NN compound xxxx True False\n",
      "rates rate NOUN NNS dobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "ORRs orr NOUN NNS appos XXXx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "preserved preserve VERB VBN amod xxxx True False\n",
      "health health NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "related relate VERB VBN amod xxxx True False\n",
      "quality quality NOUN NN conj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "life life NOUN NN pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "HR HR PROPN NNP compound XX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "QOL QOL PROPN NNP appos XXX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "to to ADP IN prep xx True True\n",
      "a a DET DT det x True True\n",
      "greater great ADJ JJR amod xxxx True False\n",
      "extent extent NOUN NN pobj xxxx True False\n",
      "than than ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "in in ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "double double ADJ JJ amod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "blind blind ADJ JJ amod xxxx True False\n",
      "COMBI combi NOUN NN compound XXXX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "d d ADJ JJ compound x True False\n",
      "study study NOUN NN pobj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "in in ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "open open ADJ JJ amod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "label label NOUN NN compound xxxx True False\n",
      "COMBI COMBI PROPN NNP compound XXXX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "v v PROPN NNP compound x True False\n",
      "study study NOUN NN pobj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "in in ADP IN prep xx True True\n",
      "two two NUM CD nummod xxx True True\n",
      "large large ADJ JJ amod xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "randomized randomize VERB VBN conj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "phase phase NOUN NN compound xxxx True False\n",
      "III iii NUM CD compound XXX True False\n",
      "studies study NOUN NNS pobj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "naÃ¯ve naã¯ve NUM CD punct xxX¯xx False False\n",
      "patients patient NOUN NNS dobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "BRAF BRAF PROPN NNP nmod XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600E V600E PROPN NNP nmod XdddX False False\n",
      "/ / SYM SYM punct / False False\n",
      "K K PROPN NNP nmod X True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Limited limited ADJ JJ amod Xxxxx True False\n",
      "treatment treatment NOUN NN compound xxxx True False\n",
      "benefit benefit NOUN NN nsubjpass xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "the the DET DT det xxx True True\n",
      "combination combination NOUN NN pobj xxxx True False\n",
      "was be VERB VBD auxpass xxx True True\n",
      "also also ADV RB advmod xxxx True True\n",
      "seen see VERB VBN ROOT xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "who who PRON WP nsubj xxx True True\n",
      "had have VERB VBD aux xxx True True\n",
      "progressed progress VERB VBN relcl xxxx True False\n",
      "on on ADP IN prep xx True True\n",
      "prior prior ADJ JJ amod xxxx True False\n",
      "BRAF BRAF PROPN NNP compound XXXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "therapy therapy NOUN NN pobj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "as as ADP IN mark xx True True\n",
      "indicated indicate VERB VBN advcl xxxx True False\n",
      "by by ADP IN agent xx True True\n",
      "ORRs orr NOUN NNS pobj XXXx True False\n",
      "of of ADP IN prep xx True True\n",
      "â‰¤ â‰¤ SYM $ nmod x‰¤ False False\n",
      "15Â 15â NUM CD nummod ddX False False\n",
      "% % NOUN NN pobj % False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "stable stable ADJ JJ amod xxxx True False\n",
      "disease disease NOUN NN conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "â‰¤ â‰¤ SYM $ pobj x‰¤ False False\n",
      "50Â 50â NUM CD nummod ddX False False\n",
      "% % NOUN NN dobj % False False\n",
      "of of ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "small small ADJ JJ amod xxxx True False\n",
      "phase phase NOUN NN nmod xxxx True False\n",
      "I -PRON- PRON PRP nmod X True True\n",
      "and and CCONJ CC cc xxx True True\n",
      "II II PROPN NNP conj XX True False\n",
      "studies study NOUN NNS pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Combination combination NOUN NN compound Xxxxx True False\n",
      "therapy therapy NOUN NN nsubj xxxx True False\n",
      "did do VERB VBD aux xxx True True\n",
      "not not ADV RB neg xxx True True\n",
      "increase increase VERB VB ROOT xxxx True False\n",
      "overall overall ADJ JJ amod xxxx True False\n",
      "toxicity toxicity NOUN NN dobj xxxx True False\n",
      "relative relative ADJ JJ amod xxxx True False\n",
      "to to ADP IN prep xx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      "monotherapy monotherapy NOUN NN advmod xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "with with ADP IN prep xxxx True True\n",
      "most most ADJ JJS amod xxxx True True\n",
      "adverse adverse ADJ JJ amod xxxx True False\n",
      "events event NOUN NNS pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "AEs AEs PROPN NNP appos XXx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mild mild ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "moderate moderate ADJ JJ conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "severity severity NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "generally generally ADV RB advmod xxxx True False\n",
      "manageable manageable ADJ JJ conj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Fewer few ADJ JJR amod Xxxxx True False\n",
      "skin skin NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "related relate VERB VBN amod xxxx True False\n",
      "AEs ae NOUN NNS nsubjpass XXx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "e.g. e.g. X FW amod x.x. False False\n",
      "cutaneous cutaneous ADJ JJ amod xxxx True False\n",
      "malignancies malignancy NOUN NNS appos xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "hyperkeratinosis hyperkeratinosis NOUN NN conj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "hand hand NOUN NN compound xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "foot foot NOUN NN compound xxxx True False\n",
      "syndrome syndrome NOUN NN conj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "were be VERB VBD auxpass xxxx True True\n",
      "reported report VERB VBN ROOT xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "combination combination NOUN NN compound xxxx True False\n",
      "therapy therapy NOUN NN pobj xxxx True False\n",
      "than than ADP IN prep xxxx True True\n",
      "with with ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "probably probably ADV RB advmod xxxx True False\n",
      "because because ADP IN prep xxxx True True\n",
      "of of ADP IN pcomp xx True True\n",
      "reduced reduced ADJ JJ amod xxxx True False\n",
      "paradoxical paradoxical ADJ JJ amod xxxx True False\n",
      "activation activation NOUN NN pobj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "MAPK MAPK PROPN NNP compound XXXX True False\n",
      "pathway pathway NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Thus thus ADV RB advmod Xxxx True True\n",
      ", , PUNCT , punct , False False\n",
      "dabrafenib dabrafenib NOUN NN nsubj xxxx True False\n",
      "plus plus CCONJ CC cc xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "provides provide VERB VBZ ROOT xxxx True False\n",
      "an an DET DT det xx True True\n",
      "important important ADJ JJ amod xxxx True False\n",
      "treatment treatment NOUN NN compound xxxx True False\n",
      "option option NOUN NN dobj xxxx True False\n",
      "for for ADP IN prep xxx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "BRAF BRAF PROPN NNP pobj XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600 V600 PROPN NNP subtok Xddd False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "positive positive ADJ JJ amod xxxx True False\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN appos xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "4 --> Combination therapy did not increase overall toxicity relative to dabrafenib or vemurafenib monotherapy, with most adverse events (AEs) mild or moderate in severity and generally manageable. \n",
      " sentiment --> 0.0 \n",
      "\n",
      "entity:\n",
      "vemurafenib 1231 1242 drug\n",
      "\n",
      " Token:\n",
      "The the DET DT det Xxx True True\n",
      "BRAF BRAF PROPN NNP compound XXXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "dabrafenib dabrafenib NOUN NN nsubjpass xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "Tafinlar(Â Tafinlar(Â PROPN NNP compound Xxxxx(X False False\n",
      "® ® PROPN NNP appos ® False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "the the DET DT det xxx True True\n",
      "MEK MEK PROPN NNP compound XXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "Mekinist(Â Mekinist(Â PROPN NNP compound Xxxxx(X False False\n",
      "® ® PROPN NNP appos ® False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "are be VERB VBP auxpass xxx True True\n",
      "indicated indicate VERB VBN ROOT xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "as as ADP IN advmod xx True True\n",
      "monotherapy monotherapy ADV RB advmod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "in in ADP IN advcl xx True True\n",
      "combination combination NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "each each DET DT det xxxx True True\n",
      "other other ADJ JJ pobj xxxx True True\n",
      ", , PUNCT , punct , False False\n",
      "for for ADP IN conj xxx True True\n",
      "the the DET DT det xxx True True\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "a a DET DT det x True True\n",
      "BRAF BRAF PROPN NNP nmod XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600 V600 PROPN NNP subtok Xddd False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "This this DET DT det Xxxx True True\n",
      "article article NOUN NN nsubj xxxx True False\n",
      "reviews review VERB VBZ ROOT xxxx True False\n",
      "the the DET DT det xxx True True\n",
      "therapeutic therapeutic ADJ JJ amod xxxx True False\n",
      "efficacy efficacy NOUN NN dobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "tolerability tolerability NOUN NN conj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "combination combination NOUN NN compound xxxx True False\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "this this DET DT det xxxx True True\n",
      "indication indication NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "summarizes summarize VERB VBZ conj xxxx True False\n",
      "relevant relevant ADJ JJ amod xxxx True False\n",
      "pharmacological pharmacological ADJ JJ amod xxxx True False\n",
      "data datum NOUN NNS dobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "Dabrafenib Dabrafenib PROPN NNP nsubj Xxxxx True False\n",
      "plus plus CCONJ CC cc xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "significantly significantly ADV RB advmod xxxx True False\n",
      "prolonged prolong VERB VBD amod xxxx True False\n",
      "progression progression NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "free free ADJ JJ amod xxxx True False\n",
      "survival survival NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "PFS PFS PROPN NNP appos XXX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "overall overall ADJ JJ amod xxxx True False\n",
      "survival survival NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "OS OS PROPN NNP appos XX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ", , PUNCT , punct , False False\n",
      "improved improve VERB VBN ROOT xxxx True False\n",
      "objective objective ADJ JJ amod xxxx True False\n",
      "response response NOUN NN compound xxxx True False\n",
      "rates rate NOUN NNS dobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "ORRs orr NOUN NNS appos XXXx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "preserved preserve VERB VBN amod xxxx True False\n",
      "health health NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "related relate VERB VBN amod xxxx True False\n",
      "quality quality NOUN NN conj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "life life NOUN NN pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "HR HR PROPN NNP compound XX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "QOL QOL PROPN NNP appos XXX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "to to ADP IN prep xx True True\n",
      "a a DET DT det x True True\n",
      "greater great ADJ JJR amod xxxx True False\n",
      "extent extent NOUN NN pobj xxxx True False\n",
      "than than ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "in in ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "double double ADJ JJ amod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "blind blind ADJ JJ amod xxxx True False\n",
      "COMBI combi NOUN NN compound XXXX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "d d ADJ JJ compound x True False\n",
      "study study NOUN NN pobj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "in in ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "open open ADJ JJ amod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "label label NOUN NN compound xxxx True False\n",
      "COMBI COMBI PROPN NNP compound XXXX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "v v PROPN NNP compound x True False\n",
      "study study NOUN NN pobj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "in in ADP IN prep xx True True\n",
      "two two NUM CD nummod xxx True True\n",
      "large large ADJ JJ amod xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "randomized randomize VERB VBN conj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "phase phase NOUN NN compound xxxx True False\n",
      "III iii NUM CD compound XXX True False\n",
      "studies study NOUN NNS pobj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "naÃ¯ve naã¯ve NUM CD punct xxX¯xx False False\n",
      "patients patient NOUN NNS dobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "BRAF BRAF PROPN NNP nmod XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600E V600E PROPN NNP nmod XdddX False False\n",
      "/ / SYM SYM punct / False False\n",
      "K K PROPN NNP nmod X True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Limited limited ADJ JJ amod Xxxxx True False\n",
      "treatment treatment NOUN NN compound xxxx True False\n",
      "benefit benefit NOUN NN nsubjpass xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "the the DET DT det xxx True True\n",
      "combination combination NOUN NN pobj xxxx True False\n",
      "was be VERB VBD auxpass xxx True True\n",
      "also also ADV RB advmod xxxx True True\n",
      "seen see VERB VBN ROOT xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "who who PRON WP nsubj xxx True True\n",
      "had have VERB VBD aux xxx True True\n",
      "progressed progress VERB VBN relcl xxxx True False\n",
      "on on ADP IN prep xx True True\n",
      "prior prior ADJ JJ amod xxxx True False\n",
      "BRAF BRAF PROPN NNP compound XXXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "therapy therapy NOUN NN pobj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "as as ADP IN mark xx True True\n",
      "indicated indicate VERB VBN advcl xxxx True False\n",
      "by by ADP IN agent xx True True\n",
      "ORRs orr NOUN NNS pobj XXXx True False\n",
      "of of ADP IN prep xx True True\n",
      "â‰¤ â‰¤ SYM $ nmod x‰¤ False False\n",
      "15Â 15â NUM CD nummod ddX False False\n",
      "% % NOUN NN pobj % False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "stable stable ADJ JJ amod xxxx True False\n",
      "disease disease NOUN NN conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "â‰¤ â‰¤ SYM $ pobj x‰¤ False False\n",
      "50Â 50â NUM CD nummod ddX False False\n",
      "% % NOUN NN dobj % False False\n",
      "of of ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "small small ADJ JJ amod xxxx True False\n",
      "phase phase NOUN NN nmod xxxx True False\n",
      "I -PRON- PRON PRP nmod X True True\n",
      "and and CCONJ CC cc xxx True True\n",
      "II II PROPN NNP conj XX True False\n",
      "studies study NOUN NNS pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Combination combination NOUN NN compound Xxxxx True False\n",
      "therapy therapy NOUN NN nsubj xxxx True False\n",
      "did do VERB VBD aux xxx True True\n",
      "not not ADV RB neg xxx True True\n",
      "increase increase VERB VB ROOT xxxx True False\n",
      "overall overall ADJ JJ amod xxxx True False\n",
      "toxicity toxicity NOUN NN dobj xxxx True False\n",
      "relative relative ADJ JJ amod xxxx True False\n",
      "to to ADP IN prep xx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      "monotherapy monotherapy NOUN NN advmod xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "with with ADP IN prep xxxx True True\n",
      "most most ADJ JJS amod xxxx True True\n",
      "adverse adverse ADJ JJ amod xxxx True False\n",
      "events event NOUN NNS pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "AEs AEs PROPN NNP appos XXx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mild mild ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "moderate moderate ADJ JJ conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "severity severity NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "generally generally ADV RB advmod xxxx True False\n",
      "manageable manageable ADJ JJ conj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Fewer few ADJ JJR amod Xxxxx True False\n",
      "skin skin NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "related relate VERB VBN amod xxxx True False\n",
      "AEs ae NOUN NNS nsubjpass XXx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "e.g. e.g. X FW amod x.x. False False\n",
      "cutaneous cutaneous ADJ JJ amod xxxx True False\n",
      "malignancies malignancy NOUN NNS appos xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "hyperkeratinosis hyperkeratinosis NOUN NN conj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "hand hand NOUN NN compound xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "foot foot NOUN NN compound xxxx True False\n",
      "syndrome syndrome NOUN NN conj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "were be VERB VBD auxpass xxxx True True\n",
      "reported report VERB VBN ROOT xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "combination combination NOUN NN compound xxxx True False\n",
      "therapy therapy NOUN NN pobj xxxx True False\n",
      "than than ADP IN prep xxxx True True\n",
      "with with ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "probably probably ADV RB advmod xxxx True False\n",
      "because because ADP IN prep xxxx True True\n",
      "of of ADP IN pcomp xx True True\n",
      "reduced reduced ADJ JJ amod xxxx True False\n",
      "paradoxical paradoxical ADJ JJ amod xxxx True False\n",
      "activation activation NOUN NN pobj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "MAPK MAPK PROPN NNP compound XXXX True False\n",
      "pathway pathway NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Thus thus ADV RB advmod Xxxx True True\n",
      ", , PUNCT , punct , False False\n",
      "dabrafenib dabrafenib NOUN NN nsubj xxxx True False\n",
      "plus plus CCONJ CC cc xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "provides provide VERB VBZ ROOT xxxx True False\n",
      "an an DET DT det xx True True\n",
      "important important ADJ JJ amod xxxx True False\n",
      "treatment treatment NOUN NN compound xxxx True False\n",
      "option option NOUN NN dobj xxxx True False\n",
      "for for ADP IN prep xxx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "BRAF BRAF PROPN NNP pobj XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600 V600 PROPN NNP subtok Xddd False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "positive positive ADJ JJ amod xxxx True False\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN appos xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "5 --> Fewer skin-related AEs (e.g. cutaneous malignancies, hyperkeratinosis and hand-foot syndrome) were reported with combination therapy than with dabrafenib or vemurafenib, probably because of reduced paradoxical activation of the MAPK pathway. \n",
      " sentiment --> 0.0 \n",
      "\n",
      "entity:\n",
      "vemurafenib 1499 1510 drug\n",
      "\n",
      " Token:\n",
      "The the DET DT det Xxx True True\n",
      "BRAF BRAF PROPN NNP compound XXXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "dabrafenib dabrafenib NOUN NN nsubjpass xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "Tafinlar(Â Tafinlar(Â PROPN NNP compound Xxxxx(X False False\n",
      "® ® PROPN NNP appos ® False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "the the DET DT det xxx True True\n",
      "MEK MEK PROPN NNP compound XXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "Mekinist(Â Mekinist(Â PROPN NNP compound Xxxxx(X False False\n",
      "® ® PROPN NNP appos ® False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "are be VERB VBP auxpass xxx True True\n",
      "indicated indicate VERB VBN ROOT xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "as as ADP IN advmod xx True True\n",
      "monotherapy monotherapy ADV RB advmod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "in in ADP IN advcl xx True True\n",
      "combination combination NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "each each DET DT det xxxx True True\n",
      "other other ADJ JJ pobj xxxx True True\n",
      ", , PUNCT , punct , False False\n",
      "for for ADP IN conj xxx True True\n",
      "the the DET DT det xxx True True\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "a a DET DT det x True True\n",
      "BRAF BRAF PROPN NNP nmod XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600 V600 PROPN NNP subtok Xddd False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "This this DET DT det Xxxx True True\n",
      "article article NOUN NN nsubj xxxx True False\n",
      "reviews review VERB VBZ ROOT xxxx True False\n",
      "the the DET DT det xxx True True\n",
      "therapeutic therapeutic ADJ JJ amod xxxx True False\n",
      "efficacy efficacy NOUN NN dobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "tolerability tolerability NOUN NN conj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "combination combination NOUN NN compound xxxx True False\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "this this DET DT det xxxx True True\n",
      "indication indication NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "summarizes summarize VERB VBZ conj xxxx True False\n",
      "relevant relevant ADJ JJ amod xxxx True False\n",
      "pharmacological pharmacological ADJ JJ amod xxxx True False\n",
      "data datum NOUN NNS dobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "Dabrafenib Dabrafenib PROPN NNP nsubj Xxxxx True False\n",
      "plus plus CCONJ CC cc xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "significantly significantly ADV RB advmod xxxx True False\n",
      "prolonged prolong VERB VBD amod xxxx True False\n",
      "progression progression NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "free free ADJ JJ amod xxxx True False\n",
      "survival survival NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "PFS PFS PROPN NNP appos XXX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "overall overall ADJ JJ amod xxxx True False\n",
      "survival survival NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "OS OS PROPN NNP appos XX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ", , PUNCT , punct , False False\n",
      "improved improve VERB VBN ROOT xxxx True False\n",
      "objective objective ADJ JJ amod xxxx True False\n",
      "response response NOUN NN compound xxxx True False\n",
      "rates rate NOUN NNS dobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "ORRs orr NOUN NNS appos XXXx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "preserved preserve VERB VBN amod xxxx True False\n",
      "health health NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "related relate VERB VBN amod xxxx True False\n",
      "quality quality NOUN NN conj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "life life NOUN NN pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "HR HR PROPN NNP compound XX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "QOL QOL PROPN NNP appos XXX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "to to ADP IN prep xx True True\n",
      "a a DET DT det x True True\n",
      "greater great ADJ JJR amod xxxx True False\n",
      "extent extent NOUN NN pobj xxxx True False\n",
      "than than ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "in in ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "double double ADJ JJ amod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "blind blind ADJ JJ amod xxxx True False\n",
      "COMBI combi NOUN NN compound XXXX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "d d ADJ JJ compound x True False\n",
      "study study NOUN NN pobj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "in in ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "open open ADJ JJ amod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "label label NOUN NN compound xxxx True False\n",
      "COMBI COMBI PROPN NNP compound XXXX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "v v PROPN NNP compound x True False\n",
      "study study NOUN NN pobj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "in in ADP IN prep xx True True\n",
      "two two NUM CD nummod xxx True True\n",
      "large large ADJ JJ amod xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "randomized randomize VERB VBN conj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "phase phase NOUN NN compound xxxx True False\n",
      "III iii NUM CD compound XXX True False\n",
      "studies study NOUN NNS pobj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "naÃ¯ve naã¯ve NUM CD punct xxX¯xx False False\n",
      "patients patient NOUN NNS dobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "BRAF BRAF PROPN NNP nmod XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600E V600E PROPN NNP nmod XdddX False False\n",
      "/ / SYM SYM punct / False False\n",
      "K K PROPN NNP nmod X True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Limited limited ADJ JJ amod Xxxxx True False\n",
      "treatment treatment NOUN NN compound xxxx True False\n",
      "benefit benefit NOUN NN nsubjpass xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "the the DET DT det xxx True True\n",
      "combination combination NOUN NN pobj xxxx True False\n",
      "was be VERB VBD auxpass xxx True True\n",
      "also also ADV RB advmod xxxx True True\n",
      "seen see VERB VBN ROOT xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "who who PRON WP nsubj xxx True True\n",
      "had have VERB VBD aux xxx True True\n",
      "progressed progress VERB VBN relcl xxxx True False\n",
      "on on ADP IN prep xx True True\n",
      "prior prior ADJ JJ amod xxxx True False\n",
      "BRAF BRAF PROPN NNP compound XXXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "therapy therapy NOUN NN pobj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "as as ADP IN mark xx True True\n",
      "indicated indicate VERB VBN advcl xxxx True False\n",
      "by by ADP IN agent xx True True\n",
      "ORRs orr NOUN NNS pobj XXXx True False\n",
      "of of ADP IN prep xx True True\n",
      "â‰¤ â‰¤ SYM $ nmod x‰¤ False False\n",
      "15Â 15â NUM CD nummod ddX False False\n",
      "% % NOUN NN pobj % False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "stable stable ADJ JJ amod xxxx True False\n",
      "disease disease NOUN NN conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "â‰¤ â‰¤ SYM $ pobj x‰¤ False False\n",
      "50Â 50â NUM CD nummod ddX False False\n",
      "% % NOUN NN dobj % False False\n",
      "of of ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "small small ADJ JJ amod xxxx True False\n",
      "phase phase NOUN NN nmod xxxx True False\n",
      "I -PRON- PRON PRP nmod X True True\n",
      "and and CCONJ CC cc xxx True True\n",
      "II II PROPN NNP conj XX True False\n",
      "studies study NOUN NNS pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Combination combination NOUN NN compound Xxxxx True False\n",
      "therapy therapy NOUN NN nsubj xxxx True False\n",
      "did do VERB VBD aux xxx True True\n",
      "not not ADV RB neg xxx True True\n",
      "increase increase VERB VB ROOT xxxx True False\n",
      "overall overall ADJ JJ amod xxxx True False\n",
      "toxicity toxicity NOUN NN dobj xxxx True False\n",
      "relative relative ADJ JJ amod xxxx True False\n",
      "to to ADP IN prep xx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      "monotherapy monotherapy NOUN NN advmod xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "with with ADP IN prep xxxx True True\n",
      "most most ADJ JJS amod xxxx True True\n",
      "adverse adverse ADJ JJ amod xxxx True False\n",
      "events event NOUN NNS pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "AEs AEs PROPN NNP appos XXx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mild mild ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "moderate moderate ADJ JJ conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "severity severity NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "generally generally ADV RB advmod xxxx True False\n",
      "manageable manageable ADJ JJ conj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Fewer few ADJ JJR amod Xxxxx True False\n",
      "skin skin NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "related relate VERB VBN amod xxxx True False\n",
      "AEs ae NOUN NNS nsubjpass XXx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "e.g. e.g. X FW amod x.x. False False\n",
      "cutaneous cutaneous ADJ JJ amod xxxx True False\n",
      "malignancies malignancy NOUN NNS appos xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "hyperkeratinosis hyperkeratinosis NOUN NN conj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "hand hand NOUN NN compound xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "foot foot NOUN NN compound xxxx True False\n",
      "syndrome syndrome NOUN NN conj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "were be VERB VBD auxpass xxxx True True\n",
      "reported report VERB VBN ROOT xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "combination combination NOUN NN compound xxxx True False\n",
      "therapy therapy NOUN NN pobj xxxx True False\n",
      "than than ADP IN prep xxxx True True\n",
      "with with ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "probably probably ADV RB advmod xxxx True False\n",
      "because because ADP IN prep xxxx True True\n",
      "of of ADP IN pcomp xx True True\n",
      "reduced reduced ADJ JJ amod xxxx True False\n",
      "paradoxical paradoxical ADJ JJ amod xxxx True False\n",
      "activation activation NOUN NN pobj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "MAPK MAPK PROPN NNP compound XXXX True False\n",
      "pathway pathway NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Thus thus ADV RB advmod Xxxx True True\n",
      ", , PUNCT , punct , False False\n",
      "dabrafenib dabrafenib NOUN NN nsubj xxxx True False\n",
      "plus plus CCONJ CC cc xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "provides provide VERB VBZ ROOT xxxx True False\n",
      "an an DET DT det xx True True\n",
      "important important ADJ JJ amod xxxx True False\n",
      "treatment treatment NOUN NN compound xxxx True False\n",
      "option option NOUN NN dobj xxxx True False\n",
      "for for ADP IN prep xxx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "BRAF BRAF PROPN NNP pobj XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600 V600 PROPN NNP subtok Xddd False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "positive positive ADJ JJ amod xxxx True False\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN appos xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "6 --> Thus, dabrafenib plus trametinib provides an important treatment option for patients with BRAF (V600) mutation-positive unresectable or metastatic melanoma.\n",
      " \n",
      " sentiment --> 0.0 \n",
      "\n",
      "entity:\n",
      "trametinib 1606 1616 drug\n",
      "BRAF 1674 1678 gene\n",
      "V600 1680 1684 varient\n",
      "melanoma 1731 1739 diesease\n",
      "\n",
      " Token:\n",
      "The the DET DT det Xxx True True\n",
      "BRAF BRAF PROPN NNP compound XXXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "dabrafenib dabrafenib NOUN NN nsubjpass xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "Tafinlar(Â Tafinlar(Â PROPN NNP compound Xxxxx(X False False\n",
      "® ® PROPN NNP appos ® False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "the the DET DT det xxx True True\n",
      "MEK MEK PROPN NNP compound XXX True False\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "Mekinist(Â Mekinist(Â PROPN NNP compound Xxxxx(X False False\n",
      "® ® PROPN NNP appos ® False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "are be VERB VBP auxpass xxx True True\n",
      "indicated indicate VERB VBN ROOT xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "as as ADP IN advmod xx True True\n",
      "monotherapy monotherapy ADV RB advmod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "in in ADP IN advcl xx True True\n",
      "combination combination NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "each each DET DT det xxxx True True\n",
      "other other ADJ JJ pobj xxxx True True\n",
      ", , PUNCT , punct , False False\n",
      "for for ADP IN conj xxx True True\n",
      "the the DET DT det xxx True True\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "a a DET DT det x True True\n",
      "BRAF BRAF PROPN NNP nmod XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600 V600 PROPN NNP subtok Xddd False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "This this DET DT det Xxxx True True\n",
      "article article NOUN NN nsubj xxxx True False\n",
      "reviews review VERB VBZ ROOT xxxx True False\n",
      "the the DET DT det xxx True True\n",
      "therapeutic therapeutic ADJ JJ amod xxxx True False\n",
      "efficacy efficacy NOUN NN dobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "tolerability tolerability NOUN NN conj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "combination combination NOUN NN compound xxxx True False\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "this this DET DT det xxxx True True\n",
      "indication indication NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "summarizes summarize VERB VBZ conj xxxx True False\n",
      "relevant relevant ADJ JJ amod xxxx True False\n",
      "pharmacological pharmacological ADJ JJ amod xxxx True False\n",
      "data datum NOUN NNS dobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n",
      "Dabrafenib Dabrafenib PROPN NNP nsubj Xxxxx True False\n",
      "plus plus CCONJ CC cc xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "significantly significantly ADV RB advmod xxxx True False\n",
      "prolonged prolong VERB VBD amod xxxx True False\n",
      "progression progression NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "free free ADJ JJ amod xxxx True False\n",
      "survival survival NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "PFS PFS PROPN NNP appos XXX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "overall overall ADJ JJ amod xxxx True False\n",
      "survival survival NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "OS OS PROPN NNP appos XX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      ", , PUNCT , punct , False False\n",
      "improved improve VERB VBN ROOT xxxx True False\n",
      "objective objective ADJ JJ amod xxxx True False\n",
      "response response NOUN NN compound xxxx True False\n",
      "rates rate NOUN NNS dobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "ORRs orr NOUN NNS appos XXXx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "preserved preserve VERB VBN amod xxxx True False\n",
      "health health NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "related relate VERB VBN amod xxxx True False\n",
      "quality quality NOUN NN conj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "life life NOUN NN pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "HR HR PROPN NNP compound XX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "QOL QOL PROPN NNP appos XXX True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "to to ADP IN prep xx True True\n",
      "a a DET DT det x True True\n",
      "greater great ADJ JJR amod xxxx True False\n",
      "extent extent NOUN NN pobj xxxx True False\n",
      "than than ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "in in ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "double double ADJ JJ amod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "blind blind ADJ JJ amod xxxx True False\n",
      "COMBI combi NOUN NN compound XXXX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "d d ADJ JJ compound x True False\n",
      "study study NOUN NN pobj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "in in ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "open open ADJ JJ amod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "label label NOUN NN compound xxxx True False\n",
      "COMBI COMBI PROPN NNP compound XXXX True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "v v PROPN NNP compound x True False\n",
      "study study NOUN NN pobj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "in in ADP IN prep xx True True\n",
      "two two NUM CD nummod xxx True True\n",
      "large large ADJ JJ amod xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "randomized randomize VERB VBN conj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "phase phase NOUN NN compound xxxx True False\n",
      "III iii NUM CD compound XXX True False\n",
      "studies study NOUN NNS pobj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "treatment treatment NOUN NN pobj xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "naÃ¯ve naã¯ve NUM CD punct xxX¯xx False False\n",
      "patients patient NOUN NNS dobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "BRAF BRAF PROPN NNP nmod XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600E V600E PROPN NNP nmod XdddX False False\n",
      "/ / SYM SYM punct / False False\n",
      "K K PROPN NNP nmod X True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Limited limited ADJ JJ amod Xxxxx True False\n",
      "treatment treatment NOUN NN compound xxxx True False\n",
      "benefit benefit NOUN NN nsubjpass xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "the the DET DT det xxx True True\n",
      "combination combination NOUN NN pobj xxxx True False\n",
      "was be VERB VBD auxpass xxx True True\n",
      "also also ADV RB advmod xxxx True True\n",
      "seen see VERB VBN ROOT xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "who who PRON WP nsubj xxx True True\n",
      "had have VERB VBD aux xxx True True\n",
      "progressed progress VERB VBN relcl xxxx True False\n",
      "on on ADP IN prep xx True True\n",
      "prior prior ADJ JJ amod xxxx True False\n",
      "BRAF BRAF PROPN NNP compound XXXX True False\n",
      "inhibitor inhibitor NOUN NN compound xxxx True False\n",
      "therapy therapy NOUN NN pobj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "as as ADP IN mark xx True True\n",
      "indicated indicate VERB VBN advcl xxxx True False\n",
      "by by ADP IN agent xx True True\n",
      "ORRs orr NOUN NNS pobj XXXx True False\n",
      "of of ADP IN prep xx True True\n",
      "â‰¤ â‰¤ SYM $ nmod x‰¤ False False\n",
      "15Â 15â NUM CD nummod ddX False False\n",
      "% % NOUN NN pobj % False False\n",
      "and and CCONJ CC cc xxx True True\n",
      "stable stable ADJ JJ amod xxxx True False\n",
      "disease disease NOUN NN conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "â‰¤ â‰¤ SYM $ pobj x‰¤ False False\n",
      "50Â 50â NUM CD nummod ddX False False\n",
      "% % NOUN NN dobj % False False\n",
      "of of ADP IN prep xx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "small small ADJ JJ amod xxxx True False\n",
      "phase phase NOUN NN nmod xxxx True False\n",
      "I -PRON- PRON PRP nmod X True True\n",
      "and and CCONJ CC cc xxx True True\n",
      "II II PROPN NNP conj XX True False\n",
      "studies study NOUN NNS pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Combination combination NOUN NN compound Xxxxx True False\n",
      "therapy therapy NOUN NN nsubj xxxx True False\n",
      "did do VERB VBD aux xxx True True\n",
      "not not ADV RB neg xxx True True\n",
      "increase increase VERB VB ROOT xxxx True False\n",
      "overall overall ADJ JJ amod xxxx True False\n",
      "toxicity toxicity NOUN NN dobj xxxx True False\n",
      "relative relative ADJ JJ amod xxxx True False\n",
      "to to ADP IN prep xx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      "monotherapy monotherapy NOUN NN advmod xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "with with ADP IN prep xxxx True True\n",
      "most most ADJ JJS amod xxxx True True\n",
      "adverse adverse ADJ JJ amod xxxx True False\n",
      "events event NOUN NNS pobj xxxx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "AEs AEs PROPN NNP appos XXx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mild mild ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "moderate moderate ADJ JJ conj xxxx True False\n",
      "in in ADP IN prep xx True True\n",
      "severity severity NOUN NN pobj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "generally generally ADV RB advmod xxxx True False\n",
      "manageable manageable ADJ JJ conj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Fewer few ADJ JJR amod Xxxxx True False\n",
      "skin skin NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "related relate VERB VBN amod xxxx True False\n",
      "AEs ae NOUN NNS nsubjpass XXx True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "e.g. e.g. X FW amod x.x. False False\n",
      "cutaneous cutaneous ADJ JJ amod xxxx True False\n",
      "malignancies malignancy NOUN NNS appos xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "hyperkeratinosis hyperkeratinosis NOUN NN conj xxxx True False\n",
      "and and CCONJ CC cc xxx True True\n",
      "hand hand NOUN NN compound xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "foot foot NOUN NN compound xxxx True False\n",
      "syndrome syndrome NOUN NN conj xxxx True False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "were be VERB VBD auxpass xxxx True True\n",
      "reported report VERB VBN ROOT xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "combination combination NOUN NN compound xxxx True False\n",
      "therapy therapy NOUN NN pobj xxxx True False\n",
      "than than ADP IN prep xxxx True True\n",
      "with with ADP IN prep xxxx True True\n",
      "dabrafenib dabrafenib NOUN NN pobj xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "vemurafenib vemurafenib NOUN NN conj xxxx True False\n",
      ", , PUNCT , punct , False False\n",
      "probably probably ADV RB advmod xxxx True False\n",
      "because because ADP IN prep xxxx True True\n",
      "of of ADP IN pcomp xx True True\n",
      "reduced reduced ADJ JJ amod xxxx True False\n",
      "paradoxical paradoxical ADJ JJ amod xxxx True False\n",
      "activation activation NOUN NN pobj xxxx True False\n",
      "of of ADP IN prep xx True True\n",
      "the the DET DT det xxx True True\n",
      "MAPK MAPK PROPN NNP compound XXXX True False\n",
      "pathway pathway NOUN NN pobj xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "Thus thus ADV RB advmod Xxxx True True\n",
      ", , PUNCT , punct , False False\n",
      "dabrafenib dabrafenib NOUN NN nsubj xxxx True False\n",
      "plus plus CCONJ CC cc xxxx True False\n",
      "trametinib trametinib NOUN NN conj xxxx True False\n",
      "provides provide VERB VBZ ROOT xxxx True False\n",
      "an an DET DT det xx True True\n",
      "important important ADJ JJ amod xxxx True False\n",
      "treatment treatment NOUN NN compound xxxx True False\n",
      "option option NOUN NN dobj xxxx True False\n",
      "for for ADP IN prep xxx True True\n",
      "patients patient NOUN NNS pobj xxxx True False\n",
      "with with ADP IN prep xxxx True True\n",
      "BRAF BRAF PROPN NNP pobj XXXX True False\n",
      "( ( PUNCT -LRB- punct ( False False\n",
      "V600 V600 PROPN NNP subtok Xddd False False\n",
      ") ) PUNCT -RRB- punct ) False False\n",
      "mutation mutation NOUN NN npadvmod xxxx True False\n",
      "- - PUNCT HYPH punct - False False\n",
      "positive positive ADJ JJ amod xxxx True False\n",
      "unresectable unresectable ADJ JJ amod xxxx True False\n",
      "or or CCONJ CC cc xx True True\n",
      "metastatic metastatic ADJ JJ conj xxxx True False\n",
      "melanoma melanoma NOUN NN appos xxxx True False\n",
      ". . PUNCT . punct . False False\n",
      "\n",
      " \n",
      " SPACE _SP  \n",
      " False False\n"
     ]
    }
   ],
   "source": [
    "for i,sent in enumerate(doc_nlp_custom.sents):\n",
    "    print(i,\"-->\",sent.text,\"\\n\",\\\n",
    "          \"sentiment -->\", sent.sentiment,\"\\n\")\n",
    "    \n",
    "    # Geting Entity\n",
    "    print( \"entity:\")\n",
    "    for ent in sent.ents:\n",
    "        print(ent.text,ent.start_char, ent.end_char, ent.label_)\n",
    "        \n",
    "    print(\"\\n\",\"Token:\")\n",
    "    \n",
    "    # Getting Token\n",
    "    for token in doc_nlp_custom:\n",
    "        print(token.text, token.lemma_, token.pos_, token.tag_, token.dep_,\n",
    "            token.shape_, token.is_alpha, token.is_stop)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 86,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "0.0\n",
      "0.0\n",
      "0.0\n",
      "0.0\n",
      "0.0\n",
      "0.0\n",
      "0.0\n"
     ]
    }
   ],
   "source": [
    "for sent in doc_nlp_custom.sents:\n",
    "    print(sent.sentiment)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": []
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": []
  },
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {},
   "outputs": [],
   "source": [
    "# Load your usual SpaCy model (one of SpaCy English models)\n",
    "import spacy\n",
    "nlp = spacy.load('en_core_web_sm')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "# Add neural coref to SpaCy's pipe\n",
    "import neuralcoref"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "neuralcoref.add_to_pipe(nlp)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "coref = neuralcoref.NeuralCoref(nlp.vocab)\n",
    "nlp.add_pipe(coref, name='neuralcoref')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "# You're done. You can now use NeuralCoref as you usually manipulate a SpaCy document annotations.\n",
    "doc = nlp(u'My sister has a dog. She loves him.')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "doc._.has_coref\n",
    "doc._.coref_clusters"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# Navigating Parse Tree"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "#!/usr/bin/env python\n",
    "# coding: utf8\n",
    "\"\"\"This example shows how to navigate the parse tree including subtrees\n",
    "attached to a word.\n",
    "\n",
    "Based on issue #252:\n",
    "\"In the documents and tutorials the main thing I haven't found is\n",
    "examples on how to break sentences down into small sub thoughts/chunks. The\n",
    "noun_chunks is handy, but having examples on using the token.head to find small\n",
    "(near-complete) sentence chunks would be neat. Lets take the example sentence:\n",
    "\"displaCy uses CSS and JavaScript to show you how computers understand language\"\n",
    "\n",
    "This sentence has two main parts (XCOMP & CCOMP) according to the breakdown:\n",
    "[displaCy] uses CSS and Javascript [to + show]\n",
    "show you how computers understand [language]\n",
    "\n",
    "I'm assuming that we can use the token.head to build these groups.\"\n",
    "\n",
    "Compatible with: spaCy v2.0.0+\n",
    "Last tested with: v2.1.0\n",
    "\"\"\"\n",
    "from __future__ import unicode_literals, print_function\n",
    "\n",
    "import plac\n",
    "import spacy\n",
    "\n",
    "\n",
    "@plac.annotations(model=(\"Model to load\", \"positional\", None, str))\n",
    "\n",
    "def main(model=\"en_core_web_sm\"):\n",
    "    nlp = spacy.load(model)\n",
    "    print(\"Loaded model '%s'\" % model)\n",
    "\n",
    "    doc = nlp(\n",
    "        \"displaCy uses CSS and JavaScript to show you how computers \"\n",
    "        \"understand language\"\n",
    "    )"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "    # The easiest way is to find the head of the subtree you want, and then use\n",
    "    # the `.subtree`, `.children`, `.lefts` and `.rights` iterators. `.subtree`\n",
    "    # is the one that does what you're asking for most directly:\n",
    "    for word in doc:\n",
    "        if word.dep_ in (\"xcomp\", \"ccomp\"):\n",
    "            print(\"\".join(w.text_with_ws for w in word.subtree))\n",
    "\n",
    "    # It'd probably be better for `word.subtree` to return a `Span` object\n",
    "    # instead of a generator over the tokens. If you want the `Span` you can\n",
    "    # get it via the `.right_edge` and `.left_edge` properties. The `Span`\n",
    "    # object is nice because you can easily get a vector, merge it, etc.\n",
    "    for word in doc:\n",
    "        if word.dep_ in (\"xcomp\", \"ccomp\"):\n",
    "            subtree_span = doc[word.left_edge.i : word.right_edge.i + 1]\n",
    "            print(subtree_span.text, \"|\", subtree_span.root.text)\n",
    "\n",
    "    # You might also want to select a head, and then select a start and end\n",
    "    # position by walking along its children. You could then take the\n",
    "    # `.left_edge` and `.right_edge` of those tokens, and use it to calculate\n",
    "    # a span.\n",
    "\n",
    "\n",
    "if __name__ == \"__main__\":\n",
    "    plac.call(main)\n",
    "\n",
    "    # Expected output:\n",
    "    # to show you how computers understand language\n",
    "    # how computers understand language\n",
    "    # to show you how computers understand language | show\n",
    "    # how computers understand language | understand"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": []
  }
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