diff --git a/requirements.txt b/requirements.txt
index 152f56e3..4fcd91eb 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,89 +1,66 @@
-aiofiles==23.1.0
-anyio==3.7.1
-appdirs==1.4.4
-appnope==0.1.3
-asttokens==2.2.1
-asyncpg==0.28.0
-attrs==23.1.0
-backcall==0.2.0
-beautifulsoup4==4.12.2
-biocommons.seqrepo==0.6.5
+agct==0.1.0.dev2
+aiofiles==24.1.0
+annotated-types==0.7.0
+anyio==4.4.0
+asttokens==2.4.1
+async-timeout==4.0.3
+asyncpg==0.29.0
+attrs==24.2.0
+biocommons.seqrepo==0.6.9
 bioutils==0.5.8.post1
-boto3==1.28.11
-botocore==1.31.11
-bs4==0.0.1
+boto3==1.35.4
+botocore==1.35.4
 canonicaljson==2.0.0
-certifi==2023.7.22
-charset-normalizer==3.2.0
-click==8.1.6
+certifi==2024.7.4
+charset-normalizer==3.3.2
+click==8.1.7
 coloredlogs==15.0.1
-configparser==6.0.0
-cool-seq-tool==0.5.1
-cssselect==1.2.0
-Cython==3.0.0
+configparser==7.1.0
+cool_seq_tool==0.7.0
 decorator==5.1.1
-executing==1.2.0
-fake-useragent==1.1.3
-fastapi==0.100.0
+executing==2.0.1
+fastapi==0.112.1
 fusor==0.4.1
 ga4gh.vrs==2.0.0a10
 gene-normalizer==0.4.0
 h11==0.14.0
 hgvs==1.5.4
 humanfriendly==10.0
-idna==3.4
-importlib-metadata==6.8.0
-inflection==0.5.1
-ipython==8.14.0
-jedi==0.18.2
-Jinja2==3.1.2
+idna==3.7
+importlib_metadata==8.4.0
+ipython==8.26.0
+jedi==0.19.1
+Jinja2==3.1.4
 jmespath==1.0.1
-jsonschema==3.2.0
-lxml==4.9.3
-Markdown==3.4.4
-MarkupSafe==2.1.3
-matplotlib-inline==0.1.6
-numpy==1.25.1
-pandas==2.0.3
-parse==1.19.1
+MarkupSafe==2.1.5
+matplotlib-inline==0.1.7
 Parsley==1.3
-parso==0.8.3
-pexpect==4.8.0
-pickleshare==0.7.5
-prompt-toolkit==3.0.39
-psycopg2==2.9.6
+parso==0.8.4
+pexpect==4.9.0
+polars==1.5.0
+prompt_toolkit==3.0.47
+psycopg2==2.9.9
 ptyprocess==0.7.0
-pure-eval==0.2.2
+pure_eval==0.2.3
 pydantic==2.4.2
-pyee==8.2.2
-Pygments==2.15.1
-pyliftover==0.4
-pyppeteer==1.0.2
-pyquery==2.0.0
-pyrsistent==0.19.3
-pysam==0.21.0
-python-dateutil==2.8.2
-python-jsonschema-objects==0.4.2
-pytz==2023.3
-PyYAML==6.0.1
-requests==2.31.0
-requests-html==0.10.0
-s3transfer==0.6.1
+pydantic_core==2.10.1
+Pygments==2.18.0
+pysam==0.22.1
+python-dateutil==2.9.0.post0
+requests==2.32.3
+s3transfer==0.10.2
 six==1.16.0
-sniffio==1.3.0
-soupsieve==2.4.1
-sqlparse==0.4.4
-stack-data==0.6.2
-starlette==0.27.0
+sniffio==1.3.1
+sqlparse==0.5.1
+stack-data==0.6.3
+starlette==0.38.2
 tabulate==0.9.0
-tqdm==4.65.0
-traitlets==5.9.0
-typing_extensions==4.7.1
-tzdata==2023.3
-urllib3==1.26.16
-uvicorn==0.23.1
-w3lib==2.1.1
-wcwidth==0.2.6
-websockets==10.4
+tqdm==4.66.5
+traitlets==5.14.3
+typing_extensions==4.12.2
+urllib3==1.26.19
+uvicorn==0.30.6
+wags_tails==0.1.4
+wcwidth==0.2.13
 yoyo-migrations==8.2.0
-zipp==3.16.2
+zipp==3.20.0