diff --git a/recipes/ntsm/LICENSE b/recipes/ntsm/LICENSE
new file mode 100644
index 0000000000000..9cdf82590afd0
--- /dev/null
+++ b/recipes/ntsm/LICENSE
@@ -0,0 +1,21 @@
+MIT License
+
+Copyright (c) 2021 Justin Chu
+
+Permission is hereby granted, free of charge, to any person obtaining a copy
+of this software and associated documentation files (the "Software"), to deal
+in the Software without restriction, including without limitation the rights
+to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
+copies of the Software, and to permit persons to whom the Software is
+furnished to do so, subject to the following conditions:
+
+The above copyright notice and this permission notice shall be included in all
+copies or substantial portions of the Software.
+
+THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
+IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
+FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
+AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
+LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
+OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
+SOFTWARE.
diff --git a/recipes/ntsm/build.sh b/recipes/ntsm/build.sh
new file mode 100644
index 0000000000000..3904525a2c3bb
--- /dev/null
+++ b/recipes/ntsm/build.sh
@@ -0,0 +1,33 @@
+#!/bin/bash -euo
+
+set -xe
+
+OS=$(uname)
+ARCH=$(uname -m)
+
+export M4="${BUILD_PREFIX}/bin/m4"
+export CFLAGS="${CFLAGS} -I$PREFIX/include -O3"
+export LDFLAGS="${LDFLAGS} -L$PREFIX/lib"
+export CPATH="${PREFIX}/include"
+export CXXFLAGS="${CXXFLAGS} -I${PREFIX}/include -O3 -std=c++17 -Wno-braced-scalar-init"
+export CPPFLAGS="${CPPFLAGS} -I${PREFIX}/include"
+
+if [[ "${OS}" == "Darwin" && "${ARCH}" == "arm64" ]]; then
+  export EXTRA_ARGS="--host=arm64"
+elif [[ "${OS}" == "Linux" && "${ARCH}" == "aarch64" ]]; then
+  export EXTRA_ARGS="--host=aarch64"
+else
+  export EXTRA_ARGS="--host=x86_64"
+fi
+
+autoreconf -if
+./configure --prefix="${PREFIX}" CC="${CC}" CXX="${CXX}" \
+  CFLAGS="${CFLAGS}" CXXFLAGS="${CXXFLAGS}" \
+  CPPFLAGS="${CPPFLAGS}" LDFLAGS="${LDFLAGS}" \
+  --disable-dependency-tracking --disable-silent-rules "${EXTRA_ARGS}"
+
+make -j ${CPU_COUNT}
+make install
+
+mkdir -p ${PREFIX}/bin
+cp -rf ntsm-scripts ntsmSiteGen ${PREFIX}/bin
diff --git a/recipes/ntsm/meta.yaml b/recipes/ntsm/meta.yaml
new file mode 100644
index 0000000000000..1058cec6e8994
--- /dev/null
+++ b/recipes/ntsm/meta.yaml
@@ -0,0 +1,61 @@
+{% set name = "ntsm" %}
+{% set version = "1.2.0" %}
+
+package:
+  name: {{ name }}
+  version: {{ version }}
+
+source:
+  url: https://github.com/JustinChu/ntsm/releases/download/{{ version }}/{{ name }}-{{ version }}.tar.gz
+  sha256: 5f22a42b71f7a446c45a98518bb6c18613e4fb320d21264903c661a949a7da23
+
+build:
+  skip: True  # [win]
+  number: 0
+  run_exports:
+   - {{ pin_subpackage('ntsm', max_pin="x") }}
+
+requirements:
+  build:
+   - {{ compiler('cxx') }}
+   - make
+   - autoconf
+   - automake
+   - libtool
+  host:
+   - zlib
+   - libgomp  # [linux]
+   - llvm-openmp  # [osx]
+  run:
+   - libgomp  # [linux]
+   - llvm-openmp  # [osx]
+   - python
+   - pyfaidx
+   - numpy
+   - scikit-learn
+   - pandas
+   - samtools
+   - bwa
+   - perl
+   - make
+
+test:
+  commands:
+   - ntsmCount --help
+   - ntsmVCF --help
+   - ntsmEval --help
+   - ntsmSiteGen test
+
+about:
+  home: "https://github.com/JustinChu/ntsm"
+  summary: "ntsm - Nucleotide Sequence/Sample Matcher"
+  license: MIT
+  license_family: MIT
+  license_file: LICENSE
+  dev_url: "https://github.com/JustinChu/ntsm"
+  doc_url: "https://github.com/JustinChu/ntsm/blob/{{ version }}/README.md"
+
+extra:
+  additional-platforms:
+    - linux-aarch64
+    - osx-arm64