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Question about the input GWAS summary #9

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Dragonfly1108 opened this issue Jun 13, 2024 · 0 comments
Open

Question about the input GWAS summary #9

Dragonfly1108 opened this issue Jun 13, 2024 · 0 comments

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@Dragonfly1108
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Hi Mingxuan,
The current PRS methods (SCT, SBLUP, DBSLMM, etc.) utilize a GWAS summary data set and the genotype of the target population to calculate PRS. However, if the GWAS used for Europeans to calculate PRS for Asians is of poor quality, it would be beneficial to use XPASS to attempt to calculate the PRS for Asians. However, this approach has encountered a challenge. The issue is that XPASS requires two GWAS summaries. If one has only one GWAS summary and the genotypes of the target population, what is the procedure for using XPASS to calculate PRS?

Thanks!

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