diff --git a/packages/app/src/cli/utilities/developer-platform-client.ts b/packages/app/src/cli/utilities/developer-platform-client.ts
index 30a0d75195..2560008464 100644
--- a/packages/app/src/cli/utilities/developer-platform-client.ts
+++ b/packages/app/src/cli/utilities/developer-platform-client.ts
@@ -56,6 +56,8 @@ import {DevSessionCreateMutation} from '../api/graphql/app-dev/generated/dev-ses
 import {DevSessionUpdateMutation} from '../api/graphql/app-dev/generated/dev-session-update.js'
 import {DevSessionDeleteMutation} from '../api/graphql/app-dev/generated/dev-session-delete.js'
 import {isTruthy} from '@shopify/cli-kit/node/context/utilities'
+import {blockPartnersAccess} from '@shopify/cli-kit/node/environment'
+import {BugError} from '@shopify/cli-kit/node/error'
 
 export enum ClientName {
   AppManagement = 'app-management',
@@ -77,6 +79,11 @@ export interface AppVersionIdentifiers {
 }
 
 export function allDeveloperPlatformClients(): DeveloperPlatformClient[] {
+  if (blockPartnersAccess() && isTruthy(process.env.USE_APP_MANAGEMENT_API)) {
+    return [new AppManagementClient()]
+  } else if (blockPartnersAccess()) {
+    throw new BugError('Both Partners and App Management APIs are deactivated.')
+  }
   const clients: DeveloperPlatformClient[] = [new PartnersClient()]
   if (isTruthy(process.env.USE_APP_MANAGEMENT_API)) clients.push(new AppManagementClient())
   return clients
diff --git a/packages/cli-kit/src/private/node/constants.ts b/packages/cli-kit/src/private/node/constants.ts
index 6337664367..9e04d9c1f8 100644
--- a/packages/cli-kit/src/private/node/constants.ts
+++ b/packages/cli-kit/src/private/node/constants.ts
@@ -30,6 +30,7 @@ export const environmentVariables = {
   verbose: 'SHOPIFY_FLAG_VERBOSE',
   noThemeBundling: 'SHOPIFY_CLI_NO_THEME_BUNDLING',
   bundledThemeCLI: 'SHOPIFY_CLI_BUNDLED_THEME_CLI',
+  neverUsePartnersApi: 'SHOPIFY_CLI_NEVER_USE_PARTNERS_API',
   // Variables to detect if the CLI is running in a cloud environment
   codespaces: 'CODESPACES',
   codespaceName: 'CODESPACE_NAME',
diff --git a/packages/cli-kit/src/public/node/context/fqdn.ts b/packages/cli-kit/src/public/node/context/fqdn.ts
index cfac3dbb18..3bd79ed89a 100644
--- a/packages/cli-kit/src/public/node/context/fqdn.ts
+++ b/packages/cli-kit/src/public/node/context/fqdn.ts
@@ -1,7 +1,8 @@
 import {spinFqdn} from './spin.js'
-import {AbortError} from '../error.js'
+import {AbortError, BugError} from '../error.js'
 import {serviceEnvironment} from '../../../private/node/context/service.js'
 import {DevServer, DevServerCore} from '../vendor/dev_server/DevServer.js'
+import {blockPartnersAccess} from '../environment.js'
 
 export const CouldntObtainPartnersSpinFQDNError = new AbortError(
   "Couldn't obtain the Spin FQDN for Partners when the CLI is not running from a Spin environment.",
@@ -22,6 +23,10 @@ export const NotProvidedStoreFQDNError = new AbortError(
  * @returns Fully-qualified domain of the partners service we should interact with.
  */
 export async function partnersFqdn(): Promise<string> {
+  if (blockPartnersAccess()) {
+    throw new BugError('Partners API is blocked by the SHOPIFY_CLI_NEVER_USE_PARTNERS_API environment variable.')
+  }
+
   const environment = serviceEnvironment()
   const productionFqdn = 'partners.shopify.com'
   switch (environment) {
diff --git a/packages/cli-kit/src/public/node/environment.ts b/packages/cli-kit/src/public/node/environment.ts
index 549338baf3..4ce8240663 100644
--- a/packages/cli-kit/src/public/node/environment.ts
+++ b/packages/cli-kit/src/public/node/environment.ts
@@ -1,4 +1,5 @@
 import {nonRandomUUID} from './crypto.js'
+import {isTruthy} from './context/utilities.js'
 import {environmentVariables, systemEnvironmentVariables} from '../../private/node/constants.js'
 
 /**
@@ -70,3 +71,12 @@ export function getIdentityTokenInformation(): {accessToken: string; refreshToke
     userId: nonRandomUUID(identityToken),
   }
 }
+
+/**
+ * If true, the CLI should not use the Partners API.
+ *
+ * @returns True if the SHOPIFY_CLI_NEVER_USE_PARTNERS_API environment variable is set.
+ */
+export function blockPartnersAccess(): boolean {
+  return isTruthy(getEnvironmentVariables()[environmentVariables.neverUsePartnersApi])
+}