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TGEMO.OWL
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TGEMO.OWL
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<?xml version="1.0"?>
<rdf:RDF xmlns="http://gemma.msl.ubc.ca/ont/TGEMO#"
xml:base="http://gemma.msl.ubc.ca/ont/TGEMO"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:so="http://purl.obolibrary.org/obo/so#"
xmlns:efo="http://www.ebi.ac.uk/efo/"
xmlns:obo="http://purl.obolibrary.org/obo/"
xmlns:owl="http://www.w3.org/2002/07/owl#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:xml="http://www.w3.org/XML/1998/namespace"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
xmlns:cito="http://purl.org/spar/cito/"
xmlns:core="http://purl.obolibrary.org/obo/uberon/core#"
xmlns:doap="http://usefulinc.com/ns/doap#"
xmlns:efo3="http://www.ebi.ac.uk/efo/#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:obo1="http://purl.obolibrary.org/obo#"
xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
xmlns:skos="http://www.w3.org/2004/02/skos/core#"
xmlns:chebi="http://purl.obolibrary.org/obo/chebi/"
xmlns:mondo="http://purl.obolibrary.org/obo/mondo#"
xmlns:sssom="https://w3id.org/sssom/"
xmlns:swrla="http://swrl.stanford.edu/ontologies/3.3/swrla.owl#"
xmlns:terms="http://purl.org/dc/terms/"
xmlns:vocab="https://w3id.org/semapv/vocab/"
xmlns:chebi2="http://purl.obolibrary.org/obo/chebi#"
xmlns:chebi5="http://purl.obolibrary.org/obo/chebi#2"
xmlns:chebi6="http://purl.obolibrary.org/obo/chebi#3"
xmlns:chebi7="http://purl.obolibrary.org/obo/chebi#1"
xmlns:refont="http://purl.obolibrary.org/obo/uberon/refont/"
xmlns:uberon="http://purl.obolibrary.org/obo/uberon#"
xmlns:protege="http://protege.stanford.edu/plugins/owl/protege#"
xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#"
xmlns:cellline="http://www.ebi.ac.uk/cellline#"
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
xmlns:patterns="http://www.co-ode.org/patterns#"
xmlns:cellline4="http://www.ebi.ac.uk/cellline/"
xmlns:ncbitaxon="http://purl.obolibrary.org/obo/ncbitaxon#"
xmlns:mondo-base="http://purl.obolibrary.org/obo/mondo/mondo-base#">
<owl:Ontology rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO">
<owl:versionIRI rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO"/>
<owl:imports rdf:resource="http://purl.obolibrary.org/obo/clo.owl"/>
<owl:imports rdf:resource="http://purl.obolibrary.org/obo/geno.owl"/>
<owl:imports rdf:resource="http://purl.obolibrary.org/obo/ro.owl"/>
<owl:imports rdf:resource="http://purl.obolibrary.org/obo/so.owl"/>
<owl:imports rdf:resource="http://www.geneontology.org/formats/oboInOwl"/>
<owl:imports rdf:resource="https://www.ebi.ac.uk/efo/efo.owl"/>
<dc:contributor>Guillaume Poirier-Morency</dc:contributor>
<dc:contributor>Mahan Rafieenaini</dc:contributor>
<dc:contributor>Paul Pavlidis</dc:contributor>
<dc:creator>Nathaniel Lim</dc:creator>
<dc:language>en</dc:language>
<dc:license>Creative Commons Attribution Non Commercial 4.0 International</dc:license>
<dc:rights>Copyright 2015-2023 University of British Columbia</dc:rights>
</owl:Ontology>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Annotation properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://purl.obolibrary.org/obo/IAO_0000115 -->
<owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115">
<rdfs:label>definition</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#auto-generated-by -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#auto-generated-by"/>
<!-- http://www.geneontology.org/formats/oboInOwl#created_by -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#created_by"/>
<!-- http://www.geneontology.org/formats/oboInOwl#creation_date -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#creation_date"/>
<!-- http://www.geneontology.org/formats/oboInOwl#date -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#date"/>
<!-- http://www.geneontology.org/formats/oboInOwl#default-namespace -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#default-namespace"/>
<!-- http://www.geneontology.org/formats/oboInOwl#hasExactSynonym -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym">
<rdfs:label>has_exact_synonym</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#hasOBOFormatVersion -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBOFormatVersion">
<rdfs:label>has_obo_format_version</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#hasOBONamespace -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace">
<rdfs:label>has_obo_namespace</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym">
<rdfs:label>has_related_synonym</rdfs:label>
</owl:AnnotationProperty>
<!-- http://www.geneontology.org/formats/oboInOwl#id -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
<!-- http://www.geneontology.org/formats/oboInOwl#saved-by -->
<owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#saved-by"/>
<!-- http://www.w3.org/2000/01/rdf-schema#label -->
<owl:AnnotationProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#label"/>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Object Properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00166 -->
<owl:ObjectProperty rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00166">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000086"/>
<oboInOwl:hasDefinition>Used to indicate that the bearer was a substance provided to a subject (whether it be human, animal or cells in vitro) at the specified dose</oboInOwl:hasDefinition>
<oboInOwl:hasExactSynonym>has dose</oboInOwl:hasExactSynonym>
<rdfs:label>delivered at dose</rdfs:label>
</owl:ObjectProperty>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00167 -->
<owl:ObjectProperty rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00167">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000086"/>
<oboInOwl:hasDefinition>Expresses that the bearer (a treatment or other manipulation) was applied for the stated amount of time.</oboInOwl:hasDefinition>
<oboInOwl:hasExactSynonym>has duration</oboInOwl:hasExactSynonym>
<rdfs:label>delivered for duration</rdfs:label>
</owl:ObjectProperty>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00168 -->
<owl:ObjectProperty rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00168">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000086"/>
<oboInOwl:hasDefinition>Indicates that the bearer (e.g. an organism or part) was at the given stage of development</oboInOwl:hasDefinition>
<rdfs:label>has developmental stage</rdfs:label>
</owl:ObjectProperty>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00169 -->
<owl:ObjectProperty rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00169">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000086"/>
<obo:IAO_0000115>Used to indicate that the subject (generally a cell type) expressed the product of the object (a gene). Example: CD133+ cancer cell.</obo:IAO_0000115>
<rdfs:label>positive for product of gene</rdfs:label>
</owl:ObjectProperty>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00170 -->
<owl:ObjectProperty rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00170">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000086"/>
<obo:IAO_0000115>Used to indicate that the subject (generally a cell type) does not express the product of the object (a gene). Example: CD133- cancer cell.</obo:IAO_0000115>
<rdfs:label>negative for product of gene</rdfs:label>
</owl:ObjectProperty>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00171 -->
<owl:ObjectProperty rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00171">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002566"/>
<obo:IAO_0000115>Indicates that the Subject (typically a disease or condition) was caused to occur or be present by the specified means. Examples: spinal cord injury induced by partial transection; Myocardial infarction induced by ligation of the proximal left coronary artery.</obo:IAO_0000115>
<obo:IAO_0000232>"Causal relationship with disease as subject" looks at first glance to be this kind of thing, but the TGEMO term is used to indicate induction in a particular experiment, not a general statement about diseases.</obo:IAO_0000232>
<rdfs:label>induced by</rdfs:label>
</owl:ObjectProperty>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00183 -->
<owl:ObjectProperty rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00183">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000086"/>
<oboInOwl:hasDefinition>Used to specify that a treatment or procedure was performed at a specific location or organism part</oboInOwl:hasDefinition>
<rdfs:label>delivered to</rdfs:label>
</owl:ObjectProperty>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00201 -->
<owl:ObjectProperty rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00201">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000086"/>
<rdfs:label xml:lang="en">has child with disease</rdfs:label>
</owl:ObjectProperty>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00202 -->
<owl:ObjectProperty rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00202">
<rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000086"/>
<obo:IAO_0000115>used in the context of experimental conditions (e.g. a treatment) where the sample taken for transcriptomic analysis followed a period of time after the condition was applied/occurred</obo:IAO_0000115>
<rdfs:label xml:lang="en">sampled after</rdfs:label>
</owl:ObjectProperty>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Classes
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00000 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00000">
<obo:IAO_0000115>Root node for Temporary Gemma Ontology.</obo:IAO_0000115>
<oboInOwl:id>TGEMO:00000</oboInOwl:id>
<rdfs:label>TGEMO Root</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00001 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00001">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GENO_0000136"/>
<obo:IAO_0000115>Double negative allele. Refers both to genetic null (missing gene/knock out) and phenotypic/functional null (inactive gene product). May be overloaded for severe loss-of-function alleles also.</obo:IAO_0000115>
<oboInOwl:hasDbXref rdf:resource="http://purl.obolibrary.org/obo/GENO_0000978"/>
<oboInOwl:hasNarrowSynonym>Nullizygous</oboInOwl:hasNarrowSynonym>
<rdfs:label>Homozygous negative</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00002 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00002">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00000"/>
<obo:IAO_0000115>Parent node for all TGEMO genetic and mutation descriptors.</obo:IAO_0000115>
<rdfs:label>TGEMO Genetics/Mutations</rdfs:label>
<owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00004 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00004">
<rdfs:subClassOf rdf:resource="http://www.ebi.ac.uk/efo/EFO_0000510"/>
<obo:IAO_0000115>Overexpression of a gene. Includes non-canonical promoter driven expression.</obo:IAO_0000115>
<rdfs:label>Overexpression</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00005 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00005">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00004"/>
<obo:IAO_0000115>Overexpression of a gene. Organism is known to have only one copy of the gene.</obo:IAO_0000115>
<rdfs:label>Single-copy overexpression</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00006 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00006">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00004"/>
<obo:IAO_0000115>Overexpression of a gene. Organism is known to have only two copies of the gene.</obo:IAO_0000115>
<rdfs:label>Double-copy overexpression</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00008 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00008">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0002053"/>
<obo:IAO_0000115>A variant rendering the activity of the gene product (i.e. adoption of an active protein confirmation) independent of the need for activation such as ligand binding</obo:IAO_0000115>
<oboInOwl:id>TGEMO_00008</oboInOwl:id>
<rdfs:label>Constitutive active mutation</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00010 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00010">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00000"/>
<obo:IAO_0000115>Parent node for all TGEMO method descriptors.</obo:IAO_0000115>
<oboInOwl:id>TGEMO:00010</oboInOwl:id>
<rdfs:label>TGEMO Methods</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00011 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00011">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00000"/>
<obo:IAO_0000115>Parent node for all TGEMO internal descriptors. Used primarily for behind-the-scenes standardization.</obo:IAO_0000115>
<oboInOwl:id>TGEMO:00011</oboInOwl:id>
<rdfs:label>Gemma Internals</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00012 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00012">
<rdfs:subClassOf rdf:resource="http://www.ebi.ac.uk/efo/EFO_0002694"/>
<obo:IAO_0000115>The removal of certain proteins by the use of antibodies</obo:IAO_0000115>
<obo:IAO_0000119>https://en.wiktionary.org/wiki/immunodepletion</obo:IAO_0000119>
<rdfs:label>Immunodepletion</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00013 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00013">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00011"/>
<obo:IAO_0000115>Samples to include in Differential Expression Analysis.</obo:IAO_0000115>
<rdfs:label>DE_Include</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00014 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00014">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00011"/>
<obo:IAO_0000115>Samples to exclude in Differential Expression Analysis.</obo:IAO_0000115>
<rdfs:label>DE_Exclude</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00020 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00020">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00011"/>
<obo:IAO_0000115>Indicator for studies containing a collection of samples rather than a designed experiment with known covariates or pre-defined experimental groups.</obo:IAO_0000115>
<rdfs:label>Sample Study</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00021 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00021">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00011"/>
<obo:IAO_0000115>Indicator for studies that have a complex experimental design, and are currently incompletely curated.</obo:IAO_0000115>
<rdfs:label>Complex Design</rdfs:label>
<owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00022 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00022">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00011"/>
<obo:IAO_0000115>Indicator (Temporary Placeholder) for experiments that are a collection of studies, and will be separated internally.</obo:IAO_0000115>
<rdfs:label>SUBSET</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00032 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00032">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00011"/>
<obo:IAO_0000115>Indicator for studies that contain a technical comparison, e.g. of methodological approaches to sample preparation, rather than (or in addition to) biological ones.</obo:IAO_0000115>
<rdfs:label>Technique comparison study</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00033 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00033">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00020"/>
<obo:IAO_0000115>Indicator for sample studies containing a collection of various cell lines.</obo:IAO_0000115>
<rdfs:label>Cell Line Sample Study</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00039 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00039">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10090"/>
<obo:IAO_0000115>Cross between C57BL/6 and 129S. Generation Unknown.</obo:IAO_0000115>
<rdfs:label>B6129SF?</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00040 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00040">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10090"/>
<obo:IAO_0000115>Cross between C57BL/6J and 129S. Generation Unknown.</obo:IAO_0000115>
<rdfs:label>B6J129SF?</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00057 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00057">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00000"/>
<obo:IAO_0000115>Parent node for all TGEMO terms that are currently not assigned a parent class.</obo:IAO_0000115>
<oboInOwl:id>TGEMO:00057</oboInOwl:id>
<rdfs:label>TGEMO Unclassified</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00058 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00058">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00057"/>
<obo:IAO_0000115>Tissue that is spatially located adjacent to the tissue of interest. Adjacent tissue are assumed to be normal, but that is not necessarily always the case.</obo:IAO_0000115>
<oboInOwl:replacedBy>Use "adjacent" relation</oboInOwl:replacedBy>
<rdfs:label>Adjacent tissue</rdfs:label>
<owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00088 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00088">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00011"/>
<obo:IAO_0000115>Indicator (Temporary Placeholder) for experiments that are identified to be time consuming for curation, and will be revisited at a later time.</obo:IAO_0000115>
<oboInOwl:id>TGEMO:00088</oboInOwl:id>
<rdfs:label>Time Consuming</rdfs:label>
<owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00101 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00101">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00010"/>
<obo:IAO_0000115>A biological system intended as a model of a human disease.</obo:IAO_0000115>
<rdfs:label>Disease model</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00102 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00102">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00002"/>
<obo:IAO_0000115>An experimental procedure using direct introduction of a protein to test rescue of a phenotype rather than genetic manipulation (e.g. a transgene).</obo:IAO_0000115>
<rdfs:label>Rescue by external protein</rdfs:label>
<owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00122 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00122">
<rdfs:subClassOf rdf:resource="http://gemma.msl.ubc.ca/ont/TGEMO_00057"/>
<obo:IAO_0000115>Used to signify that a particular factor has no specified value for a particular sample. Intended as a less ambiguous alternative to "NA", "null" or "none"</obo:IAO_0000115>
<rdfs:label>Unspecified factor value</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00151 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00151">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>Fusion of the human BCR and ABL1 genes</obo:IAO_0000115>
<oboInOwl:hasBroadSynonym>Philadelphia chromosome</oboInOwl:hasBroadSynonym>
<oboInOwl:hasExactSynonym>BCR-ABL1</oboInOwl:hasExactSynonym>
<rdfs:label>BCR-ABL</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00152 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00152">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000288"/>
<obo:IAO_0000115>An engineered fusion of green fluorescent protein with another gene</obo:IAO_0000115>
<obo:IAO_0000232>Intention is that this would be related to a gene term via a predicate such as 'modified by'</obo:IAO_0000232>
<oboInOwl:hasExactSynonym>GFP-tagged</oboInOwl:hasExactSynonym>
<rdfs:label>GFP fusion</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00153 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00153">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>Fusion of the human ETV6 and RUNX1 genes, associated with childhood acute lymphoblastic leukemia</obo:IAO_0000115>
<oboInOwl:hasExactSynonym>E/R</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>ETV6/RUNX1</oboInOwl:hasExactSynonym>
<rdfs:label>ETV6-RUNX1</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00154 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00154">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000288"/>
<obo:IAO_0000115>A conditionally active form of murine GATA-1 made by fusing its coding region to the ligand-binding domain of the human estrogen receptor (ER)</obo:IAO_0000115>
<obo:IAO_0000119>https://doi.org/10.1016/S0092-8674(00)80318-9</obo:IAO_0000119>
<oboInOwl:hasExactSynonym>GATA1-ESR1</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>GATA1/ER</oboInOwl:hasExactSynonym>
<rdfs:label>GATA1-ER</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00155 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00155">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>Fusion of the human MLL and AF9 genes, associated with acute myeloid leukemia (AML)</obo:IAO_0000115>
<rdfs:label>MLL-AF9</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00156 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00156">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>Fusion of the human NUP98 and HOXA9 genes, associated with acute myeloid leukemia (AML)</obo:IAO_0000115>
<obo:IAO_0000119>doi: 10.1093/emboj/20.3.350</obo:IAO_0000119>
<rdfs:label>NUP98-HOXA9</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00157 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00157">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>Fusion of the human PML and RARA genes, associated with acute myeloid leukemia (AML)</obo:IAO_0000115>
<obo:IAO_0000119>doi: 10.3390/cancers12030624</obo:IAO_0000119>
<rdfs:label>PML-RARA</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00158 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00158">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>Fusion of the human AML1 and ETO genes, associated with acute myeloid leukemia (AML)</obo:IAO_0000115>
<obo:IAO_0000119>DOI: 10.1182/blood-2005-04-1656</obo:IAO_0000119>
<oboInOwl:hasExactSynonym>RUNX1- RUNX1T1</oboInOwl:hasExactSynonym>
<rdfs:label>AML1-ETO</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00159 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00159">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000288"/>
<obo:IAO_0000115>An engineered fusion of red fluorescent protein with another gene</obo:IAO_0000115>
<rdfs:label>RFP fusion</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00160 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00160">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000288"/>
<obo:IAO_0000115>An engineered fusion of the human interleukin (IL)-4 and IL-10 genes developed as an experimentallly to inhibit pro‐inflammatory activity in arthritis models</obo:IAO_0000115>
<obo:IAO_0000119>DOI: 10.1073/pnas.2009647118</obo:IAO_0000119>
<obo:IAO_0000119>doi: 10.1111/cei.13224</obo:IAO_0000119>
<rdfs:label>IL4-10 FP</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00162 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00162">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>fusion of the human E2A and PBX1 genes, associated with prognostically favorable precursor B-subtypes of childhood acute lymphoblastic leukemia</obo:IAO_0000115>
<obo:IAO_0000119>doi: 10.1016/S1470-2045(08)70339-5</obo:IAO_0000119>
<rdfs:label>E2A-PBX1</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00163 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00163">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>fusion of the human TEL and AML1 genes, associated with prognostically favorable precursor B-subtypes of childhood acute lymphoblastic leukemia</obo:IAO_0000115>
<obo:IAO_0000119>doi: 10.1016/S1470-2045(08)70339-5</obo:IAO_0000119>
<rdfs:label>TEL-AML1</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00164 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00164">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>Fusion of the human TMPRSS2 and ERG genes, identified in some prostate cancers</obo:IAO_0000115>
<obo:IAO_0000119>doi: 10.1126/science.1117679</obo:IAO_0000119>
<rdfs:label>TMPRSS2-ERG</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00172 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00172">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10090"/>
<obo:IAO_0000115>Alzheimer disease model. Overexpresses both mutant human amyloid beta (A4) precursor protein 695 (APP)) with the Swedish (K670N, M671L), Florida (I716V), and London (V717I) Familial Alzheimer's Disease (FAD) mutations and human PS1 harboring two FAD mutations, M146L and L286V.</obo:IAO_0000115>
<obo:IAO_0000119>https://www.jax.org/strain/008730</obo:IAO_0000119>
<oboInOwl:hasDbXref>https://www.informatics.jax.org/allele/MGI:3693208</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym>5XFAD</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>5XFAD APP/PS1</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>5XFAD line Tg6799</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Tg(APP*Swe*Fl*Lon,PSEN1*M146L*L286V)6799Vas</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Tg-5xFAD</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Tg6799</oboInOwl:hasExactSynonym>
<rdfs:label>5xFAD</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00173 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00173">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10090"/>
<obo:IAO_0000115>Alzheimer disease model. Triple transgenic homozygous with genotype APP Swedish, MAPT P301L, and PSEN1 M146V.</obo:IAO_0000115>
<obo:IAO_0000119>https://www.jax.org/strain/004807</obo:IAO_0000119>
<oboInOwl:hasDbXref>https://www.alzforum.org/research-models/3xtg</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>https://www.informatics.jax.org/strain/MGI:2673730</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>https://www.jax.org/strain/004807</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym>B6.Cg-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/J</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/J</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>C57BL/6-Psen1tm1Mpm Tg(APPSwe, tauP301L)1Lfa/J</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>C57BL/6-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/J</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>The LaFerla mouse</oboInOwl:hasExactSynonym>
<rdfs:label>3xTg-AD</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00174 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00174">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10090"/>
<obo:IAO_0000115>Alzheimer disease model. Double transgenic mice expressing a chimeric mouse/human amyloid precursor protein (Mo/HuAPP695swe) and a mutant human presenilin 1 (PS1-dE9), both directed to CNS neurons.</obo:IAO_0000115>
<obo:IAO_0000119>https://www.jax.org/strain/005864</obo:IAO_0000119>
<oboInOwl:hasDbXref>https://www.informatics.jax.org/strain/MGI:3611279</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>https://www.jax.org/strain/005864</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym>B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/J</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax</oboInOwl:hasExactSynonym>
<rdfs:label>APP/PS1</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00175 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00175">
<rdfs:subClassOf rdf:resource="http://www.ebi.ac.uk/efo/EFO_0022483"/>
<obo:IAO_0000115>Type 1 diabetes disease model. Expresses a chicken calmodulin minigene (CALM1) controlled by the rat insulin II promoter (Ins2)(Referred to as BIC). In addition, these mice express a truncated SV40 T antigen (TAg) controlled by a lens specific alpha A crystallin (Cryaa) promoter (referred to as GR19).</obo:IAO_0000115>
<obo:IAO_0000119>https://www.jax.org/strain/005564</obo:IAO_0000119>
<oboInOwl:hasDbXref>https://www.informatics.jax.org/allele/MGI:3576672</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>https://www.jax.org/strain/005564</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym>FVB(Cg)-Tg(Cryaa-Tag,Ins2-CALM1)26Ove/PneJ</oboInOwl:hasExactSynonym>
<rdfs:label>OVE26</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00176 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00176">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10090"/>
<obo:IAO_0000115>Alzheimer disease model. P301S Tg mice express the P301S mutant form of human microtubule-associated protein tau (MAPT), under the direction of the mouse prion protein promoter (Prnp).</obo:IAO_0000115>
<obo:IAO_0000119>https://www.jax.org/strain/008169</obo:IAO_0000119>
<oboInOwl:hasDbXref>https://www.alzforum.org/research-models/tau-p301s-line-ps19</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>https://www.informatics.jax.org/strain/MGI:5553124</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>https://www.jax.org/strain/008169</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym>B6N.Cg-Tg(Prnp-MAPT*P301S)PS19Vle/J</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>Tau P301S</oboInOwl:hasExactSynonym>
<rdfs:label>PS19</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00177 -->
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<obo:IAO_0000115>Huntington's Disease model. Are transgenic for the 5' end of the human HD gene carrying (CAG)115-(CAG)150 repeat expansions.</obo:IAO_0000115>
<obo:IAO_0000119>https://www.jax.org/strain/006471</obo:IAO_0000119>
<oboInOwl:hasDbXref>https://www.informatics.jax.org/strain/MGI:3692955</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>https://www.jax.org/strain/006471</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym>B6-R6/1</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>B6.Cg-Tg(HDexon1)61Gpb/J</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>HD R6/1</oboInOwl:hasExactSynonym>
<rdfs:label>R6/1</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00178 -->
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<obo:IAO_0000115>Huntington's Disease model. Transgenic for the 5' end of the human HD gene carrying approximately 120 +/- 5 CAG repeat expansions. The transgene is ubiquitously expressed.</obo:IAO_0000115>
<obo:IAO_0000119>https://www.jax.org/strain/006494</obo:IAO_0000119>
<oboInOwl:hasDbXref>https://qpsneuro.com/in-vivo-services/animal-models/huntingtons-disease-mouse-models/r6-2-transgenic-mouse-model/</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>https://www.informatics.jax.org/strain/MGI:3688746</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>https://www.jax.org/strain/006494</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym>B6CBA-R6/2 (CAG 120 +/- 5)</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>B6CBA-Tg(HDexon1)62Gpb/3J</oboInOwl:hasExactSynonym>
<rdfs:label>R6/2</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00179 -->
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<obo:IAO_0000115>Down Syndrome disease model. Ts65Dn mice have three copies of most of the genes on mouse Chr 16 that are homologues of human Chr 21 genes. These extra genes, along with the centromere and about 5% of proximal Chr 17 are contained in a small extra chromosome derived from a reciprocal translocation.</obo:IAO_0000115>
<obo:IAO_0000119>https://www.jax.org/strain/001924</obo:IAO_0000119>
<oboInOwl:hasDbXref>https://www.informatics.jax.org/strain/MGI:2163627</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>https://www.jax.org/strain/001924</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym>B6EiC3Sn a/A-Ts(1716)65Dn</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>B6EiC3Sn a/A-Ts(1716)65Dn/J</oboInOwl:hasExactSynonym>
<rdfs:label>Ts65Dn</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00180 -->
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<rdfs:subClassOf rdf:resource="http://www.ebi.ac.uk/efo/EFO_0000604"/>
<obo:IAO_0000115>Duchenne muscular dystrophy disease model. Point mutation in Dmd gene results in a termination codon (TAA) in place of a glutamine codon.This allele is predicted to produce a truncated protein.</obo:IAO_0000115>
<obo:IAO_0000119>https://www.jax.org/strain/001801</obo:IAO_0000119>
<oboInOwl:hasDbXref>https://www.informatics.jax.org/strain/MGI:2162540</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>https://www.jax.org/strain/001801</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym>C57BL/10ScSn-Dmdmdx/J</oboInOwl:hasExactSynonym>
<rdfs:label>mdx</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00181 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00181">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10090"/>
<obo:IAO_0000115>Down syndrome disease model. Trisomic for the mouse chromosome segment orthologus to the human chromosome 21 Down syndrome critical region (DSCR). The borders of the 3.9 Mb region are defined by the carbonyl reductase 1 gene and a site adjacent to the myxovirus (influenza virus) resistance 2 locus.</obo:IAO_0000115>
<obo:IAO_0000119>https://www.jax.org/strain/005383</obo:IAO_0000119>
<oboInOwl:hasDbXref>https://www.informatics.jax.org/strain/MGI:3574387</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>https://www.jax.org/strain/005383</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym>B6.129S6-Dp(16Cbr1-Fam3b)1Rhr/J</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>B6.129S6-Dp(16Cbr1-ORF9)1Rhr/J</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>B6.129S6-Is(16Cbr1-ORF9)1Rhr</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>B6.129S6-Is(16Cbr1-ORF9)1Rhr/J</oboInOwl:hasExactSynonym>
<rdfs:label>Ts1Rhr</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00182 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00182">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10090"/>
<obo:IAO_0000115>Down syndrome disease model. Mice have partial trisomy of chromosome 16.</obo:IAO_0000115>
<obo:IAO_0000119>https://www.jax.org/strain/004861</obo:IAO_0000119>
<oboInOwl:hasDbXref>https://www.informatics.jax.org/strain/MGI:2680524</oboInOwl:hasDbXref>
<oboInOwl:hasDbXref>https://www.jax.org/strain/004861</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym>B6Ei;C3Sn-Ts(1216C-tel)1Cje</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>B6EiC3Sn-Ts(1216C-tel)1Cje</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>B6EiC3Sn-Ts(16C-tel)1Cje</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>B6EiC3Sn-Ts(16C-tel)1Cje/DnJ</oboInOwl:hasExactSynonym>
<rdfs:label>Ts1Cje</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00184 -->
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<obo:IAO_0000115>There are two mouse models referred to by the name “PS2APP” to in the literature. This entry refers to the model that was generated by co-injecting two constructs into C57/BL/6 zygotes, and is also known by the name B6.152H. The other PS2APP line was generated by crossing two single transgenic animals (PS2(N141I) x APPswe) (Richards et al., 2003). Both lines of double transgenic animals express the same transgenes and both develop a similar level of cerebral pathology (Weidensteiner et al., 2009), but only the B6.152H mice show enhanced LTP. The reasons for this are not entirely clear, but differing levels of transgene expression may be partly responsible. B6.152H mice have higher expression of transgenic human APP mRNA (1.45-fold) compared to PS2APP mice and approximately 30-fold higher levels of PSEN2 mRNA. They also have about 2-fold higher Aβ levels than PS2APP mice (Poirier et al., 2010). The B6.152H line is maintained as a homozygote line. It is on a pure C57BL/6 background and shows less variability in pathology expression. It has been used to generate the TauPS2APP triple transgenic line by crossing with the Tau-overexpressing pR5 line (Grueninger et al., 2010).</obo:IAO_0000115>
<oboInOwl:hasDbXref>https://www.alzforum.org/research-models/ps2app</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym>B6.152H</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>B6.PS2APP</oboInOwl:hasExactSynonym>
<oboInOwl:hasExactSynonym>TG B6.PS2APP mice (line B6.152H)</oboInOwl:hasExactSynonym>
<rdfs:label xml:lang="en">PS2APP</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00185 -->
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<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>Fusion of the human TCF3 and PBX1 genes. Associated with B-cell childhood lymphoblastic lymphoma.</obo:IAO_0000115>
<obo:IAO_0000119>DOI: 10.1182/blood-2009-12-253419</obo:IAO_0000119>
<rdfs:label xml:lang="en">TCF3-PBX1</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00186 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00186">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>Fusion of the human MYB and GATA1 genes. Associated with acute basophilic leukaemia.</obo:IAO_0000115>
<obo:IAO_0000119>DOI: 10.1002/path.4908</obo:IAO_0000119>
<rdfs:label xml:lang="en">MYB-GATA1</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00187 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00187">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>Fusion of the human ZBTB16 and RARA genes. Associated with acute promyelocytic leukemia.</obo:IAO_0000115>
<obo:IAO_0000119>DOI: 10.1038/nm.3441</obo:IAO_0000119>
<rdfs:label xml:lang="en">ZBTB16-RARA</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00188 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00188">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>Fusion of the human IRF4 and SPIB genes. Associated with the activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL).</obo:IAO_0000115>
<obo:IAO_0000119>DOI: 10.1016/j.ccr.2012.05.024</obo:IAO_0000119>
<rdfs:label xml:lang="en">IRF4-SPIB</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00189 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00189">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000119>DOI: 10.4161/15592294.2014.988048</obo:IAO_0000119>
<obo:IAO_0000119>Fusion of the human EWS and FLI1 genes. Associated with Ewing sarcoma.</obo:IAO_0000119>
<rdfs:label xml:lang="en">EWS-FLI1</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00190 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00190">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>Fusion of the human RUNX1 and ETO genes. Associated with acute myeloid leukemia.</obo:IAO_0000115>
<obo:IAO_0000119>DOI: 10.1038/leu.2012.49</obo:IAO_0000119>
<rdfs:label xml:lang="en">RUNX1-ETO</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00191 -->
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<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>Fusion of the human YAP1 and MAMLD1 genes. Associated with supratentorial ependymoma.</obo:IAO_0000115>
<obo:IAO_0000119>DOI: 10.1038/s41556-022-01069-6</obo:IAO_0000119>
<oboInOwl:hasExactSynonym>MAMLD1-YAP1</oboInOwl:hasExactSynonym>
<rdfs:label xml:lang="en">YAP1-MAMLD1</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00192 -->
<owl:Class rdf:about="http://gemma.msl.ubc.ca/ont/TGEMO_00192">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>Fusion of the human BIRC3 and MALT1 genes. Associated with B-cell non Hodgkin lymphoma and MALT lymphoma.</obo:IAO_0000115>
<rdfs:label xml:lang="en">BIRC3-MALT1</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00193 -->
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<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10090"/>
<obo:IAO_0000115>APP23 transgenic mice have the 6.7 kbp murine Thy1 cassette driving expression of human APP isoform 751, containing the Swedish double mutation (APP751*K670N/M671L) associated with Alzheimer's disease.</obo:IAO_0000115>
<oboInOwl:hasDbXref>https://www.jax.org/strain/030504</oboInOwl:hasDbXref>
<oboInOwl:hasExactSynonym>APP K670N/M671L</oboInOwl:hasExactSynonym>
<rdfs:label xml:lang="en">APP23</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00194 -->
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<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>Fusion of the human SH3PXD2A and HTRA1 genes. The gene product of the SH3PXD2A-HTRA1 fusion has been shown to promote proliferation, invasion and resistance to cell death in vitro and tumor growth in vivo.</obo:IAO_0000115>
<obo:IAO_0000119>DOI: 10.1007/s11060-021-03796-6</obo:IAO_0000119>
<rdfs:label xml:lang="en">SH3PXD2A-HTRA1</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00195 -->
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<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000287"/>
<obo:IAO_0000115>Fusion of the ETV6 and NTRK3 genes. ETV6-NTRK3 (EN) is reported in seven different cancers.</obo:IAO_0000115>
<obo:IAO_0000119>DOI: 10.3390/cancers15174246</obo:IAO_0000119>
<rdfs:label xml:lang="en">ETV6-NTRK3</rdfs:label>
</owl:Class>
<!-- http://gemma.msl.ubc.ca/ont/TGEMO_00196 -->
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