diff --git a/client/payment-request/blocks/index.js b/client/payment-request/blocks/index.js
index 6e44c416c77..0ec5b11a2d2 100644
--- a/client/payment-request/blocks/index.js
+++ b/client/payment-request/blocks/index.js
@@ -5,6 +5,7 @@ import { PAYMENT_METHOD_NAME_PAYMENT_REQUEST } from '../../checkout/constants';
 import { PaymentRequestExpress } from './payment-request-express';
 import { applePayImage } from './apple-pay-preview';
 import { getConfig } from '../../utils/checkout';
+import { getPaymentRequest } from '../utils';
 
 const ApplePayPreview = () => <img src={ applePayImage } alt="" />;
 
@@ -12,17 +13,30 @@ const paymentRequestPaymentMethod = ( api ) => ( {
 	name: PAYMENT_METHOD_NAME_PAYMENT_REQUEST,
 	content: <PaymentRequestExpress api={ api } stripe={ api.loadStripe() } />,
 	edit: <ApplePayPreview />,
-	canMakePayment: () => {
+	canMakePayment: ( cartData ) => {
 		// If in the editor context, always return true to display the `edit` prop preview.
 		// https://github.com/woocommerce/woocommerce-gutenberg-products-block/issues/4101.
 		if ( getConfig( 'is_admin' ) ) {
 			return true;
 		}
 
-		return (
-			!! api.getStripe() &&
-			'undefined' !== typeof wcpayPaymentRequestParams
-		);
+		if ( 'undefined' === typeof wcpayPaymentRequestParams ) {
+			return false;
+		}
+
+		return api.loadStripe().then( ( stripe ) => {
+			// Create a payment request and check if we can make a payment to determine whether to
+			// show the Payment Request Button or not. This is necessary because a browser might be
+			// able to load the Stripe JS object, but not support Payment Requests.
+			const pr = getPaymentRequest( {
+				stripe,
+				total: parseInt( cartData?.cartTotals?.total_price ?? 0, 10 ),
+				requestShipping: cartData?.cartNeedsShipping,
+				displayItems: [],
+			} );
+
+			return pr.canMakePayment();
+		} );
 	},
 	paymentMethodId: PAYMENT_METHOD_NAME_PAYMENT_REQUEST,
 	supports: {